C
Charles C. Caldwell
Researcher at University of Cincinnati
Publications - 161
Citations - 6965
Charles C. Caldwell is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Sepsis & Inflammation. The author has an hindex of 41, co-authored 149 publications receiving 6000 citations. Previous affiliations of Charles C. Caldwell include Cincinnati Children's Hospital Medical Center & Medical University of South Carolina.
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Journal ArticleDOI
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.
Michail V. Sitkovsky,Dmitriy Lukashev,Sergey Apasov,Hidefumi Kojima,Masahiro Koshiba,Charles C. Caldwell,Akio Ohta,Manfred Thiel +7 more
TL;DR: A2A receptor-triggered generation of intracellular cAMP inhibits activated immune cells in a delayed negative feedback manner to prevent additional tissue damage, and targeting A2A adenosine receptors may have important clinical applications.
Journal ArticleDOI
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions.
Charles C. Caldwell,Hidefumi Kojima,Dmitriy Lukashev,John Armstrong,Mark Farber,Sergey Apasov,Michail V. Sitkovsky +6 more
TL;DR: The ambient 20% oxygen tension (plus 2-ME) is remarkably well suited for immunologic specificity and cytotoxicity studies, but oxygen dependence should be taken into account during the design and interpretation of results of in vitro T cell development assays and gene expression studies in vivo.
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Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury.
Manfred Thiel,Alexander Choukèr,Alexander Choukèr,Akio Ohta,Akio Ohta,Edward Jackson,Charles C. Caldwell,Patrick F. Smith,Dmitry Lukashev,Dmitry Lukashev,Iris Bittmann,Michail V. Sitkovsky,Michail V. Sitkovsky +12 more
TL;DR: It is shown that this potential complication of clinically widely used oxygenation procedures could be completely prevented by intratracheal injection of a selective A2AR agonist to compensate for the oxygenation-related loss of the lung tissue-protecting endogenous adenosine.
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IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis
Jacqueline Unsinger,Margaret McGlynn,Kevin R. Kasten,Kevin R. Kasten,Andrew S. Hoekzema,Eizo Watanabe,Jared T. Muenzer,Jacquelyn S. McDonough,Johannes Tschoep,Johannes Tschoep,Thomas A. Ferguson,Jonathan E. McDunn,Michel Morre,David A. Hildeman,Charles C. Caldwell,Charles C. Caldwell,Richard S. Hotchkiss +16 more
TL;DR: Rec recombinant human IL-7 efficacy and potential mechanisms of action were tested in a murine peritonitis model and showed that rhIL-7 markedly improved host survival, blocked apoptosis of CD4 and CD8 T cells, restored IFN-γ production, and improved immune effector cell recruitment to the infected site.
Journal ArticleDOI
Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.
Xiaohong Wang,Haitao Gu,Dongze Qin,Dongze Qin,Liwang Yang,Liwang Yang,Wei Huang,Kobina Essandoh,Yigang Wang,Charles C. Caldwell,Tianqing Peng,Basilia Zingarelli,Guo-Chang Fan +12 more
TL;DR: Exosomal miR-223 plays an essential role for MSC-induced cardio-protection in sepsis, and is identified as a target for down-regulation of Sema3A and Stat3 in WT-exosomes.