C
Charles Denby
Researcher at University of California
Publications - 19
Citations - 1066
Charles Denby is an academic researcher from University of California. The author has contributed to research in topics: Cannabinoid & Metabolic engineering. The author has an hindex of 10, co-authored 18 publications receiving 759 citations. Previous affiliations of Charles Denby include Joint BioEnergy Institute & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast
Xiaozhou Luo,Michael Reiter,Leo d'Espaux,Jeff Wong,Charles Denby,Anna Lechner,Yunfeng Zhang,Adrian T. Grzybowski,Simon Harth,Weiyin Lin,Hyunsu Lee,Changhua Yu,John Shin,Kai Deng,Veronica T. Benites,G. Wang,Edward E. K. Baidoo,Yan Chen,Ishaan Dev,Christopher J. Petzold,Jay D. Keasling,Jay D. Keasling +21 more
TL;DR: In this paper, the authors reported the complete biosynthesis of the major cannabinoids cannabigerolic acid, Δ9-tetrahydrocannabinolic acid and cannabidiolic acid in Saccharomyces cerevisiae, from the simple sugar galactose.
Journal Article
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast (2019) (vol 567, pg 123, 2019)
Xiaozhou Luo,Michael Reiter,Leo d'Espaux,Jeff Wong,Charles Denby,Anna Lechner,Yunfeng Zhang,Adrian T. Grzybowski,Simon Harth,Weiyin Lin,Hyunsu Lee,Changhua Yu,John Shin,Kai Deng,Veronica T. Benites,G. Wang,Baidoo Eek,Yan Chen,Ishaan Dev,Christopher J. Petzold,Jay D. Keasling +20 more
TL;DR: This work engineered the native mevalonate pathway to provide a high flux of geranyl pyrophosphate and introduced a heterologous, multi-organism-derived hexanoyl-CoA biosynthetic pathway that harnessed the promiscuity of several pathway genes to produce cannabinoid analogues.
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Industrial brewing yeast engineered for the production of primary flavor determinants in hopped beer.
Charles Denby,Charles Denby,Rachel Li,Rachel Li,Rachel Li,Van T. Vu,Zak Costello,Zak Costello,Weiyin Lin,Weiyin Lin,Leanne Jade G. Chan,Leanne Jade G. Chan,Joseph Williams,Bryan R. Donaldson,Charles W. Bamforth,Christopher J. Petzold,Christopher J. Petzold,Henrik Vibe Scheller,Henrik Vibe Scheller,Henrik Vibe Scheller,Hector Garcia Martin,Hector Garcia Martin,Jay D. Keasling +22 more
TL;DR: It is reported that brewer’s yeast can be engineered to biosynthesize aromatic monoterpene molecules that impart hoppy flavor to beer by incorporating recombinant DNA derived from yeast, mint, and basil.
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Production and quantification of sesquiterpenes in Saccharomyces cerevisiae, including extraction, detection and quantification of terpene products and key related metabolites
Sarah Rodriguez,Sarah Rodriguez,James Kirby,James Kirby,Charles Denby,Charles Denby,Jay D. Keasling +6 more
TL;DR: This work details procedures for extraction and detection of the key pathway metabolites MEV, squalene and ergosterol, as well as the farnesyl pyrophosphate (FPP)-derived side products farnesol and nerolidol, which are important for quality control.
Journal ArticleDOI
Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines.
Brian R. Ott,Brian R. Ott,Richard N. Jones,Lori A. Daiello,Suzanne M. de la Monte,Suzanne M. de la Monte,Edward G. Stopa,Edward G. Stopa,Conrad E. Johanson,Charles Denby,Paula Grammas +10 more
TL;DR: The results of the current study suggest that changes in BCSFB function resulting in altered permeability and transport are related to expression of specific inflammatory proteins, and that the shifting distribution of these proteins from serum to CSF in AD and MCI is correlated with more severe perturbations in B CSFB function.