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Conrad E. Johanson
Researcher at Brown University
Publications - 177
Citations - 9209
Conrad E. Johanson is an academic researcher from Brown University. The author has contributed to research in topics: Choroid plexus & Cerebrospinal fluid. The author has an hindex of 50, co-authored 177 publications receiving 8296 citations. Previous affiliations of Conrad E. Johanson include University of Kansas & Rhode Island Hospital.
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Journal ArticleDOI
Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
Conrad E. Johanson,John A Duncan,Petra M. Klinge,Thomas Brinker,Edward G. Stopa,Gerald D. Silverberg +5 more
TL;DR: This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics: formation rate, pressure, flow, volume, turnover rate, composition, recycling and reabsorption.
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RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease
John E. Donahue,Stephanie Flaherty,Conrad E. Johanson,John A Duncan,Gerald D. Silverberg,Miles C. Miller,Rosemarie Tavares,Wentian Yang,Qian Wu,Edmond Sabo,Virginia Hovanesian,Edward G. Stopa +11 more
TL;DR: The data confirm that AD is associated with changes in the relative distribution of RAGE and LRP-1 receptors in human hippocampus and suggest that the proportion of amyloid within the brains of AD patients that is derived from the systemic circulation may be significant.
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Microvascular injury and blood-brain barrier leakage in Alzheimer's disease.
B.D. Zipser,Conrad E. Johanson,Liliana Gonzalez,Tyler M. Berzin,Rosemarie Tavares,Christine M. Hulette,Michael P. Vitek,Virginia Hovanesian,Edward G. Stopa +8 more
TL;DR: Evidence is provided that in advanced AD (Braak stage V-VI), plasma proteins like prothrombin can be found within the microvessel wall and surrounding neuropil, and that leakage of the blood-brain barrier may be more common in patients with at least one APOE4 allele.
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Chemotherapy delivery issues in central nervous system malignancy: a reality check.
Leslie L. Muldoon,Carole Soussain,Kristoph Jahnke,Conrad E. Johanson,Tali Siegal,Quentin R. Smith,Walter A. Hall,Kullervo Hynynen,Peter D. Senter,David M. Peereboom,Edward A. Neuwelt +10 more
TL;DR: Because of the difficulty in treating CNS tumors, innovative treatments and alternative delivery techniques involving brain/cord capillaries, choroid plexus, and CSF are needed.
Journal ArticleDOI
A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans
TL;DR: The CP/CSF, the third circulation, performs many functions comparable to the kidney including nourishing the brain and contributing to a stable internal milieu for the brain.