Charles E. Vejnar

TL;DR: It is shown that targeting Cas9 to the germ line using a Cas9-nanos 3′ UTR led to the generation of maternal-zygotic mutants, as well as increased viability and decreased somatic mutations.

TL;DR: These results identify micropeptide‐encoding genes in vertebrates, providing an entry point to define their function in vivo, and suggest functional peptide products (micropeptides).

TL;DR: It is shown that rhythmic transcription extends to the locus specifying miR-122, a highly abundant, hepatocyte-specific microRNA, and the identification of Pparbeta/delta and the peroxisome proliferator-activated receptor alpha (PPARalpha) coactivator Smarcd1/Baf60a as novel miR,122 targets suggests an involvement of the circadian metabolic regulators of the PPAR family in miR -122-mediated metabolic control.

TL;DR: An open-source software library, miRmap, which for the first time comprehensively covers all four approaches using 11 predictor features, 3 of which are novel, and concludes that target site accessibility appears to be the most predictive feature.

TL;DR: It is shown that the codon triplet contains translation‐dependent regulatory information that influences transcript decay, and shapes maternal mRNA clearance during the maternal‐to‐zygotic transition in zebrafish, Xenopus, mouse, and Drosophila, and gene expression during homeostasis across human tissues.