D
David Gatfield
Researcher at University of Lausanne
Publications - 51
Citations - 7861
David Gatfield is an academic researcher from University of Lausanne. The author has contributed to research in topics: Circadian clock & Messenger RNA. The author has an hindex of 25, co-authored 44 publications receiving 6873 citations. Previous affiliations of David Gatfield include University of Geneva & European Bioinformatics Institute.
Papers
More filters
Journal ArticleDOI
SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
Gad Asher,David Gatfield,Markus Stratmann,Hans Reinke,Charna Dibner,Florian Kreppel,Raul Mostoslavsky,Frederick W. Alt,Ueli Schibler +8 more
TL;DR: It is shown that SIRT1, an NAD(+)-dependent protein deacetylase, is required for high-magnitude circadian transcription of several core clock genes, including Bmal1, Rorgamma, Per2, and Cry1.
Journal ArticleDOI
Mammalian genes are transcribed with widely different bursting kinetics
David M. Suter,Nacho Molina,David Gatfield,David Gatfield,Kim Schneider,Ueli Schibler,Felix Naef +6 more
TL;DR: This work established various gene trap cell lines and transgenic cell lines expressing a short-lived luciferase protein from an unstable mRNA, and recorded bioluminescence in real time in single cells, demonstrating that bursting kinetics are highly gene-specific.
Journal ArticleDOI
The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
TL;DR: The composition of the exon–exon junction complex is dynamic in vivo and is subject to significant evolution upon mRNA export to the cytoplasm.
Journal ArticleDOI
A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing
TL;DR: It is shown that the RNA-binding protein GW182 and the DCP1:DCP2 decapping complex are required for miRNA-mediated gene silencing, uncovering a crucial role for P-body components in the miRNA pathway.
Journal ArticleDOI
REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
Gwendal Le Martelot,Thierry Claudel,David Gatfield,Olivier Schaad,Benoît Kornmann,Giuseppe Lo Sasso,Antonio Moschetta,Ulrich Schibler +7 more
TL;DR: The nuclear receptor REV-ERBα shapes the daily activity profile of Sterol Response Element Binding Protein (SREBP) and thereby participates in the circadian control of cholesterol and bile acid synthesis in the liver.