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Charles F. Contant
Researcher at Baylor College of Medicine
Publications - 85
Citations - 7907
Charles F. Contant is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Cerebral blood flow & Cerebral perfusion pressure. The author has an hindex of 42, co-authored 85 publications receiving 7636 citations. Previous affiliations of Charles F. Contant include Baylor University & University of Southern California.
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Journal ArticleDOI
Clinical trials in head injury
Raj K. Narayan,Mary Ellen Michel,Beth Ansell,Alex Baethmann,Anat Biegon,Michael B. Bracken,M. Ross Bullock,Sung C. Choi,Guy L. Clifton,Charles F. Contant,William M. Coplin,W. Dalton Dietrich,Jamshid Ghajar,Sean M. Grady,Robert G. Grossman,Edward D. Hall,William Heetderks,David A. Hovda,Jack Jallo,Russell L. Katz,Nachshon Knoller,Patrick M. Kochanek,Andrew I R Maas,Jeannine Majde,Donald W. Marion,A Marmarou,Lawrence F. Marshall,Tracy K. McIntosh,Emmy Miller,Noel Mohberg,J. Paul Muizelaar,Lawrence H. Pitts,Peter Quinn,Gad Riesenfeld,Claudia S. Robertson,Kenneth I. Strauss,Graham M. Teasdale,Nancy Temkin,Ronald F. Tuma,Charles E. Wade,Michael D. Walker,Michael Weinrich,John Whyte,Jack E. Wilberger,A. Byron Young,Lorraine Yurkewicz +45 more
TL;DR: The pathomechanisms of traumatic brain damage, based upon their clinical importance, are discussed and a uniform strategic approach for evaluation of potentially interesting new compounds in clinical trials, to ameliorate outcome in patients with severe head injury, is proposed.
Journal ArticleDOI
Prevention of secondary ischemic insults after severe head injury.
Claudia S. Robertson,Alex B. Valadka,H. Hannay,Charles F. Contant,Shankar P. Gopinath,Manuela Cormio,Masahiko Uzura,Robert G. Grossman +7 more
TL;DR: In this paper, the authors compared the effects of two acute care management strategies on the frequency of jugular venous desaturation and refractory intracranial hypertension and on long-term neurologic outcome in patients with severe head injury.
Journal ArticleDOI
High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury
Howard M. Eisenberg,Ralph F. Frankowski,Charles F. Contant,Lawrence F. Marshall,Michael D. Walker +4 more
TL;DR: The hypothesis that high-dose pentobarbital is an effective adjunctive therapy, but that it is indicated in only a small subset of patients with severe head injury is supported.
Journal ArticleDOI
Jugular venous desaturation and outcome after head injury.
Shankar P. Gopinath,Claudia S. Robertson,Charles F. Contant,C. Hayes,Zeev Feldman,Raj K. Narayan,Robert G. Grossman +6 more
TL;DR: Although a cause and effect relationship with outcome cannot be established, the data suggest that monitoring SvO2 might allow early identification and therefore treatment of many types of secondary injury to the brain.
Journal ArticleDOI
Relationship of brain tissue PO2 to outcome after severe head injury.
TL;DR: Analysis of the PbtO2 monitoring data suggested that the likelihood of death increased with increasing duration of time at or below a PBTO2 of 15 torr (2.0 kPa) or with the occurrence of any Pbt O2 values of < or =6 torr (< or =0.8 kPa).