D
Donald W. Marion
Researcher at University of Pittsburgh
Publications - 168
Citations - 14506
Donald W. Marion is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Traumatic brain injury & Cerebral blood flow. The author has an hindex of 63, co-authored 166 publications receiving 14081 citations. Previous affiliations of Donald W. Marion include Temple University & Brain Trauma Foundation.
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Journal ArticleDOI
Lack of effect of induction of hypothermia after acute brain injury.
Guy L. Clifton,Emmy R. Miller,Sung C. Choi,Harvey S. Levin,Stephen R. McCauley,Kenneth R. Smith,Jan Paul Muizelaar,Franklin C. Wagner,Donald W. Marion,Thomas G. Luerssen,Randall M. Chesnut,Michael L. Schwartz +11 more
TL;DR: Treatment with hypothermia, with the body temperature reaching 33 degrees C within eight hours after injury, is not effective in improving outcomes in patients with severe brain injury.
Journal ArticleDOI
Treatment of Traumatic Brain Injury with Moderate Hypothermia
Donald W. Marion,Louis E. Penrod,Sheryl F. Kelsey,Walter Obrist,Patrick M. Kochanek,Alan M. Palmer,Stephen R. Wisniewski,Steven T. DeKosky +7 more
TL;DR: A randomized, controlled trial compared the effects of moderate hypothermia and normothermia in 82 patients with severe closed head injuries and found thatHypothermia may limit some of the deleterious metabolic responses of traumatic brain injury.
Journal ArticleDOI
Clinical trials in head injury
Raj K. Narayan,Mary Ellen Michel,Beth Ansell,Alex Baethmann,Anat Biegon,Michael B. Bracken,M. Ross Bullock,Sung C. Choi,Guy L. Clifton,Charles F. Contant,William M. Coplin,W. Dalton Dietrich,Jamshid Ghajar,Sean M. Grady,Robert G. Grossman,Edward D. Hall,William Heetderks,David A. Hovda,Jack Jallo,Russell L. Katz,Nachshon Knoller,Patrick M. Kochanek,Andrew I R Maas,Jeannine Majde,Donald W. Marion,A Marmarou,Lawrence F. Marshall,Tracy K. McIntosh,Emmy Miller,Noel Mohberg,J. Paul Muizelaar,Lawrence H. Pitts,Peter Quinn,Gad Riesenfeld,Claudia S. Robertson,Kenneth I. Strauss,Graham M. Teasdale,Nancy Temkin,Ronald F. Tuma,Charles E. Wade,Michael D. Walker,Michael Weinrich,John Whyte,Jack E. Wilberger,A. Byron Young,Lorraine Yurkewicz +45 more
TL;DR: The pathomechanisms of traumatic brain damage, based upon their clinical importance, are discussed and a uniform strategic approach for evaluation of potentially interesting new compounds in clinical trials, to ameliorate outcome in patients with severe head injury, is proposed.
Journal ArticleDOI
The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report
TL;DR: It is concluded that therapeutic moderate hypothermia is safe and has sustained favorable effects on acute derangements of cerebral physiology and metabolism caused by severe closed head injury.
Journal ArticleDOI
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Alan M. Palmer,Donald W. Marion,Michelle L. Botscheller,Pamela E. Swedlow,Scott D. Styren,Steven T. DeKosky +5 more
TL;DR: Remarkably similar histological injuries were produced by this procedure, supporting the notion that TBI is an excitotoxic injury.