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Charles J. Dimitroff
Researcher at FIU Herbert Wertheim College of Medicine
Publications - 60
Citations - 3067
Charles J. Dimitroff is an academic researcher from FIU Herbert Wertheim College of Medicine. The author has contributed to research in topics: Galectin & Cancer. The author has an hindex of 31, co-authored 52 publications receiving 2763 citations. Previous affiliations of Charles J. Dimitroff include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Targeting selectins and selectin ligands in inflammation and cancer
TL;DR: Antagonists that target cellular interactions with E-selectin and other members of the selectin family, including neutralizing monoclonal antibodies, competitive ligand inhibitors or metabolic carbohydrate mimetics, exemplify a growing arsenal of potentially effective therapeutics in controlling inflammation and the metastatic behavior of cancer.
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CD44 is a major E-selectin ligand on human hematopoietic progenitor cells.
Charles J. Dimitroff,Charles J. Dimitroff,Jack Y. Lee,Jack Y. Lee,Shahin Rafii,Robert C. Fuhlbrigge,Robert C. Fuhlbrigge,Robert Sackstein +7 more
TL;DR: A shear-based adherence assay is used to analyze and define the E-selectin ligand activity of membrane proteins from human HPCs and offers new insights into the structural biology and physiology of CD44, and into the molecular basis of E- selectin–dependent adhesive interactions that direct homing of human H PC to BM.
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A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells.
TL;DR: It is shown here that hematopoietic cell L-selectin ligand is a specialized glycoform of CD44, which requires sialofucosylated N-linked glycans and is sulfation-independent.
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Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin.
TL;DR: It is demonstrated for the first time that human bone-metastatic prostate tumor cells roll on human BMECs under physiological flow conditions, and the importance of both glycoprotein(s) and glycosphingolipid structures displaying sialyl Lewis X epitopes as potential E-selectin ligand expression is established.
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Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking
Steven R. Barthel,Georg K. Wiese,Jaehyung Cho,Jaehyung Cho,Matthew J. Opperman,Danielle L. Hays,Javed Siddiqui,Kenneth J. Pienta,Bruce Furie,Charles J. Dimitroff +9 more
TL;DR: Results indicate that α1,3 FTs could enhance metastatic efficiency of PCa by triggering an E-selectin-dependent trafficking mechanism.