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Charles J. Dimitroff
Researcher at FIU Herbert Wertheim College of Medicine
Publications - 60
Citations - 3067
Charles J. Dimitroff is an academic researcher from FIU Herbert Wertheim College of Medicine. The author has contributed to research in topics: Galectin & Cancer. The author has an hindex of 31, co-authored 52 publications receiving 2763 citations. Previous affiliations of Charles J. Dimitroff include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct Incorporation
Steven R. Barthel,Steven R. Barthel,Aristotelis Antonopoulos,Filiberto Cedeno-Laurent,Filiberto Cedeno-Laurent,Lana Schaffer,Gilberto E. Hernandez,Shilpa A. Patil,Simon J. North,Anne Dell,Khushi L. Matta,Sriram Neelamegham,Stuart M. Haslam,Charles J. Dimitroff,Charles J. Dimitroff +14 more
TL;DR: Data show that Gal-1 and E-selectin ligand reduction by 4-F-GlcNAc is not caused by direct 4- F-GlCNAc glycan incorporation and consequent chain termination but rather by interference with UDP-Gl cNAc synthesis.
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Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression
Keiichi Yamanaka,Charles J. Dimitroff,Robert C. Fuhlbrigge,Masato Kakeda,Ichiro Kurokawa,Hitoshi Mizutani,Thomas S. Kupper +6 more
TL;DR: It is suggested that 1,25D(3) can selectively downregulate CLA expression without influencing lymphocyte migration patterns to other tissues.
Journal ArticleDOI
Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity.
Filiberto Cedeno-Laurent,Filiberto Cedeno-Laurent,Matthew J. Opperman,Steven R. Barthel,Steven R. Barthel,Danielle L. Hays,Tobias Schatton,Tobias Schatton,Qian Zhan,Xiaoying He,Khushi L. Matta,Jeffrey G. Supko,Markus H. Frank,Markus H. Frank,George F. Murphy,George F. Murphy,Charles J. Dimitroff,Charles J. Dimitroff +17 more
TL;DR: The data suggest that metabolic lowering of Gal-1-binding N-acetyllactosamines may attenuate tumor growth by boosting antitumor immune cell levels, representing a promising approach for cancer immunotherapy.
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The 130-kDa Glycoform of CD43 Functions as an E-Selectin Ligand for Activated Th1 Cells In Vitro and in Delayed-Type Hypersensitivity Reactions In Vivo
Pilar Alcaide,Sandra L. King,Charles J. Dimitroff,Yaw-Chyn Lim,Robert C. Fuhlbrigge,Francis W. Luscinskas +5 more
TL;DR: It is demonstrated that both PSGL-1 and CD43 are major E-selectin ligands and are likely to be important during leukocyte recruitment in the development of inflammatory reactions.
Journal ArticleDOI
Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin.
Steven R. Barthel,Jacyln D Gavino,Georg K. Wiese,Jennifer M Jaynes,Javed Siddiqui,Charles J. Dimitroff +5 more
TL;DR: The results implicate the importance of alpha1,3 FT3, FT6, and/or FT7 in sLe(X) and ESL synthesis on metastatic PCa cells and contrast the expression level of glycosyltransferases in ESL(+) MDA cells among other ESL(-) metastaticPCa cell lines.