J
Jeffery L. Kutok
Researcher at Brigham and Women's Hospital
Publications - 224
Citations - 30109
Jeffery L. Kutok is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Haematopoiesis & Leukemia. The author has an hindex of 85, co-authored 221 publications receiving 27653 citations. Previous affiliations of Jeffery L. Kutok include Harvard University & Stony Brook University.
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Journal ArticleDOI
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
Margaret A. Shipp,Kenneth N. Ross,Pablo Tamayo,Andrew P. Weng,Jeffery L. Kutok,Ricardo C.T. Aguiar,Michelle Gaasenbeek,Michael Angelo,Michael R. Reich,Geraldine S. Pinkus,Tane S. Ray,Margaret A. Koval,Andrew Norton,T. Andrew Lister,Jill P. Mesirov,Donna Neuberg,Eric S. Lander,Jon C. Aster,Todd R. Golub +18 more
TL;DR: Genes implicated in DLBCL outcome included some that regulate responses to B-cell–receptor signaling, critical serine/threonine phosphorylation pathways and apoptosis, and identify rational targets for intervention.
Journal ArticleDOI
Regulation of the Germinal Center Response by MicroRNA-155
To-Ha Thai,Dinis Pedro Calado,Stefano Casola,K. Mark Ansel,Changchun Xiao,Yingzi Xue,Andrew J. Murphy,David Frendewey,David M. Valenzuela,Jeffery L. Kutok,Marc Schmidt-Supprian,Nikolaus Rajewsky,George D. Yancopoulos,Anjana Rao,Klaus Rajewsky +14 more
TL;DR: It is shown that the evolutionarily conserved microRNA-155 has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response.
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Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
Michael R. Green,Stefano Monti,Scott J. Rodig,Przemyslaw Juszczynski,Treeve Currie,Evan O'Donnell,Bjoern Chapuy,Kunihiko Takeyama,Donna Neuberg,Todd R. Golub,Jeffery L. Kutok,Margaret A. Shipp +11 more
TL;DR: High-resolution copy number data with transcriptional profiles are integrated and identified the immunoregulatory genes, PD-L1 andPD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines, defining the PD-1 pathway and JAK2 as complementary rational therapeutic targets.
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PI3Kγ is a molecular switch that controls immune suppression
Megan M. Kaneda,Karen Messer,Natacha Ralainirina,Hongying Li,Christopher J. Leem,Sara Gorjestani,Gyunghwi Woo,Abraham V. Nguyen,Camila C. Figueiredo,Camila C. Figueiredo,Philippe Foubert,Michael C. Schmid,Melissa Pink,David G. Winkler,Matthew Rausch,Vito J. Palombella,Jeffery L. Kutok,Karen McGovern,Kelly A. Frazer,Xuefeng Wu,Michael Karin,Roman Sasik,Ezra E.W. Cohen,Judith A. Varner +23 more
TL;DR: This work demonstrates that therapeutic targeting of intracellular signalling pathways that regulate the switch between macrophage polarization states can control immune suppression in cancer and other disorders.
Journal ArticleDOI
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
Stefano Monti,Kerry J. Savage,Jeffery L. Kutok,Friedrich Feuerhake,Paul J. Kurtin,Martin C. Mihm,Bingyan Wu,Laura Pasqualucci,Donna Neuberg,Ricardo C.T. Aguiar,Paola Dal Cin,Christine Ladd,Geraldine S. Pinkus,Gilles Salles,Nancy L. Harris,Riccardo Dalla-Favera,Thomas M. Habermann,Jon C. Aster,Todd R. Golub,Todd R. Golub,Margaret A. Shipp +20 more
TL;DR: Tumor microenvironment and host inflammatory response as defining features in DLBCL are identified and rational treatment targets in specificDLBCL subsets are suggested.