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Charles J. Lowenstein
Researcher at University of Rochester Medical Center
Publications - 190
Citations - 28984
Charles J. Lowenstein is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 68, co-authored 181 publications receiving 27741 citations. Previous affiliations of Charles J. Lowenstein include University of Texas Southwestern Medical Center & United States Department of Veterans Affairs.
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Journal ArticleDOI
Nitric oxide: a physiologic mediator of penile erection
TL;DR: No is established as a physiologic mediator of erectile function and small doses of NO synthase inhibitors abolished electrophysiologically induced penile erections.
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Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide
Charles J. Lowenstein,Evan W. Alley,Prafulla Raval,Adele M. Snowman,Solomon H. Snyder,Stephen W. Russell,William J. Murphy +6 more
TL;DR: Delineation of these two cooperative regions explains at the level of transcription how IFN-gamma and LPS act in concert to induce maximally the mac-NOS gene and, furthermore, howIFN-Gamma augments the inflammatory response to LPS.
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MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
TL;DR: It is shown that endothelial cells express microRNA 126 (miR-126), which inhibits VCAM-1 expression and suggests that microRNA can regulate adhesion molecule expression and may provide additional control of vascular inflammation.
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Nitric oxide: A physiologic messenger
TL;DR: A noxious, unstable gas, nitric oxide, a byproduct of automobile exhaust, electric power stations, and lightning, was discovered in the body, where it participates in various functions, including suppression of pathogens, vasodilation, and neurotransmission, focusing on its clinical relevance.
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Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.
David A. Geller,Charles J. Lowenstein,Richard A. Shapiro,Andreas K. Nussler,M. Di Silvio,Stewart C. Wang,Don K. Nakayama,Richard L. Simmons,S H Snyder,Timothy R. Billiar +9 more
TL;DR: Hep-NOS appears to be an inducible form of NOS that is distinct from mac-N OS as well as brain and endothelial NOS isozymes.