W
William J. Murphy
Researcher at University of California, Davis
Publications - 191
Citations - 15121
William J. Murphy is an academic researcher from University of California, Davis. The author has contributed to research in topics: Immunotherapy & Immune system. The author has an hindex of 52, co-authored 181 publications receiving 13263 citations. Previous affiliations of William J. Murphy include University of Nevada, Reno & Johns Hopkins University.
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Journal ArticleDOI
Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide
Charles J. Lowenstein,Evan W. Alley,Prafulla Raval,Adele M. Snowman,Solomon H. Snyder,Stephen W. Russell,William J. Murphy +6 more
TL;DR: Delineation of these two cooperative regions explains at the level of transcription how IFN-gamma and LPS act in concert to induce maximally the mac-NOS gene and, furthermore, howIFN-Gamma augments the inflammatory response to LPS.
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Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.
Rosalba Salcedo,Maria Lourdes Ponce,Howard A. Young,Ken Wasserman,Jerrold M. Ward,Hynda K. Kleinman,Joost J. Oppenheim,William J. Murphy +7 more
TL;DR: Treatment of immunodeficient mice bearing human breast carcinoma cells with a neutralizing antibody to MCP-1 resulted in significant increases in survival and inhibition of the growth of lung micrometastases, indicating that M CP-1 can act as a direct mediator of angiogenesis.
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Advances in graft-versus-host disease biology and therapy
TL;DR: This Review highlights the recent advances in understanding the pathophysiology of GVHD and its treatment, with a focus on manipulations of the immune system that are amenable to clinical application.
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Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils (∗)
Oleg Chertov,Dennis F. Michiel,Luoling Xu,Ji Ming Wang,Kenji Tani,William J. Murphy,Dan L. Longo,Dennis D. Taub,Joost J. Oppenheim +8 more
TL;DR: The antimicrobial proteins, CAP37/azurocidin and defensins H NP-1 and HNP-2, are identified as potent neutrophil-derived chemoattractants for T-cells, which represent primordial antimicrobial peptides which may have evolved into acute inflammatory cell-derived signals that mobilize immunocompetent T- cells and other inflammatory cells.
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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
Qing Zhou,Meghan E. Munger,Rachelle G. Veenstra,Brenda J. Weigel,Mitsuomi Hirashima,David H. Munn,William J. Murphy,Miyuki Azuma,Ana C. Anderson,Vijay K. Kuchroo,Bruce R. Blazar +10 more
TL;DR: Combined PD-1/PDL1 and Tim-3/galectin-9 blockade may be beneficial in preventing CD8(+) T-cell exhaustion in patients with hematologic malignancies such as advanced AML.