Cheng Gao

TL;DR: Comparison to macrophage internalized with ROS-responsive NPs, as a live-cell based drug delivery system for treatment of atherosclerosis, suggests that cell membrane coated drug delivery approach is likely more suitable for dealing with an inflammatory disease than the live- cell approach.

TL;DR: It is demonstrated that this novel pH-sensitive prodrug-nanoparticle system may provide a simple and efficient platform for the selective co-delivery of multiple drugs to tumor cells.

TL;DR: A photosensitive formulation that releases paraquat upon exposure to UV light or sunlight is generated, which shows an improved safety profile in zebrafish and mouse models, while maintaining substantial herbicidal activity.

TL;DR: A novel amphiphilic thiolated carboxymethyl chitosan synthesized into disulfide bond cross-linked nanoparticles in deionized water showed an obvious pH/redox responsibility, and may be used for tumor-specific drug release.

TL;DR: ThisMacrophage-biomimetic nanomedicine leverages the inflammatory tropism and inflammatory cytokine sequestration effects of macrophage membrane for targeted delivery and local inflammation suppression, the ROS-responsiveness of β-cyclodextrin-based matrix for specific payload release, and the macrophages-polarizing effect of rosiglitazone for inflammatory regulation, thereby exhibiting considerable therapeutic efficacy against UC in mice.