C
Chengyun Zheng
Researcher at Shandong University
Publications - 60
Citations - 2458
Chengyun Zheng is an academic researcher from Shandong University. The author has contributed to research in topics: Multiple myeloma & Telomerase reverse transcriptase. The author has an hindex of 28, co-authored 51 publications receiving 2056 citations. Previous affiliations of Chengyun Zheng include Karolinska University Hospital & Emory University.
Papers
More filters
Journal ArticleDOI
Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
Xingzhe Ma,Enguang Bi,Yong Lu,Pan Su,Chunjian Huang,Lintao Liu,Qiang Wang,Maojie Yang,Matthew F. Kalady,Jianfei Qian,Aijun Zhang,Anisha A. Gupte,Dale J. Hamilton,Chengyun Zheng,Qing Yi +14 more
TL;DR: It is reported that cholesterol in the tumor microenvironment induces CD8+ T cell expression of immune checkpoints and exhaustion and a new strategy for restoring T-cell function by reducing cholesterol to enhance T cell-based immunotherapy is suggested.
Journal ArticleDOI
Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS
TL;DR: It is demonstrated for the first time, that vascular endothelial growth factor (VEGF) delays progression of symptoms and prolongs survival in a Cu/Zn superoxide dismutase (SOD1) transgenic mouse model of ALS, suggesting that VEGF or related compounds, might be of value in the treatment of ALS patients.
Journal Article
Frequent amplification of the telomerase reverse transcriptase gene in human tumors.
Anju Zhang,Chengyun Zheng,Charlotta Lindvall,Mi Hou,Jessica Ekedahl,Rolf Lewensohn,Zhongqun Yan,Xiaoyan Yang,Marie Henriksson,Elisabeth Blennow,Magnus Nordenskjöld,Anders Zetterberg,Magnus Björkholm,Astrid Gruber,Dawei Xu +14 more
TL;DR: The present findings imply that the hTERT locus may be a frequent target for amplification during tumorigenesis and that this genetic event probably contributes to the dysregulation of telomerase activity occurring in human tumors.
Journal Article
Molecular Characterization of Human Telomerase Reverse Transcriptase-immortalized Human Fibroblasts by Gene Expression Profiling Activation of the Epiregulin Gene
Charlotta Lindvall,Mi Hou,Toshi Komurasaki,Chengyun Zheng,Marie Henriksson,John M. Sedivy,Magnus Björkholm,Bin Tean Teh,Magnus Nordenskjöld,Dawei Xu +9 more
TL;DR: HTERT-immortalized cells may not replace their normal counterparts for studies of normal cell biology and that the use of hTERT for expansion of normal human cells for therapeutic purposes must be approached with caution.
Journal ArticleDOI
Spectrum and clinical implications of syntaxin 11 gene mutations in familial haemophagocytic lymphohistiocytosis: association with disease-free remissions and haematopoietic malignancies
Eva Rudd,K Göransdotter Ericson,Chengyun Zheng,Z Uysal,A Ozkan,Aytemiz Gurgey,Bengt Fadeel,Magnus Nordenskjöld,J-I Henter +8 more
TL;DR: The results suggest that STX11 gene mutations may be associated with secondary malignancies (MDS/AML), and that there is segregation of specific clinical features in FHL patients with an underlying genotype.