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Chenxi Jia
Researcher at Protein Sciences
Publications - 39
Citations - 1133
Chenxi Jia is an academic researcher from Protein Sciences. The author has contributed to research in topics: Mass spectrometry & PKM2. The author has an hindex of 16, co-authored 34 publications receiving 844 citations. Previous affiliations of Chenxi Jia include University of Wisconsin-Madison & Tianjin University.
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Journal ArticleDOI
PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis.
Fabao Liu,Fengfei Ma,Yuyuan Wang,Ling Hao,Hao Zeng,Chenxi Jia,Yidan Wang,Peng Liu,Irene M. Ong,Baobin Li,Guojun Chen,Jiaoyang Jiang,Shaoqin Gong,Lingjun Li,Lingjun Li,Wei Xu +15 more
TL;DR: The CARM1–PKM2 axis serves as a metabolic reprogramming mechanism in tumorigenesis, and inhibiting PKM2 methylation generates metabolic vulnerability to InsP3R-dependent mitochondrial functions.
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Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.
Ruibing Chen,Yun Liu,Hao Zhuang,Hao Zhuang,Baicai Yang,Kaiwen Hei,Mingming Xiao,Chunyu Hou,Huajun Gao,Xinran Zhang,Chenxi Jia,Chenxi Jia,Lingjun Li,Lingjun Li,Yongmei Li,Ning Zhang +15 more
TL;DR: A novel mechanism by which MALAT1 regulates the activity of p53 through the lncRNA–protein interaction is uncovered by combining RNA pull-down, quantitative proteomics, bioinformatics, and experimental validation.
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Site-specific characterization of (D)-amino acid containing peptide epimers by ion mobility spectrometry.
TL;DR: A novel site-specific strategy to rapidly and precisely localize d-amino acids in peptides by ion mobility spectrometry (IMS) analysis of mass spectrometric (MS)-generated epimeric fragment ions is developed.
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Porous-CLEAs of papain: application to enzymatic hydrolysis of macromolecules.
TL;DR: Porous cross-linked enzyme aggregates (p-CLEAs) were prepared by adding starch as a pore-making agent, which facilitates CLEAs in cases where the substrates of enzyme are macromolecules.
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Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming.
Qingran Li,Lijuan Cao,Yang Tian,Pei Zhang,Chujie Ding,Wenjie Lu,Chenxi Jia,Chang Shao,Wenyue Liu,Dong Wang,Hui Ye,Haiping Hao +11 more
TL;DR: This study provides a mechanistic link between PKM2-induced metabolic remodeling and the antitumorigenic function of butyrate and demonstrates a widely applicable approach to uncovering unknown protein targets for small molecules with biological functions.