Cheryl M. Tucker

TL;DR: It is concluded that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes.

TL;DR: This work describes genetic changes that resulted from the experimental adaptation of 24 haploid and diploid cultures of Saccharomyces cerevisiae to growth in either glucose, sulfate, or phosphate-limited chemostats and suggests that experimental evolution can also shed light on the function and regulation of individual metabolic pathways.

TL;DR: The results demonstrate the existence of aneuploidy-tolerating mutations that improve the fitness of multiple different aneuPLoidies and highlight the importance of ubiquitin-proteasomal degradation in suppressing the adverse effects of anneuploids.

TL;DR: This is an example where hybrid genome resolution is driven by positive selection on existing heterozygosity and demonstrates that even infrequent outcrossing may have lasting impacts on adaptation.

TL;DR: It is reported that deletion of the FIS1 gene in yeast consistently results in acquisition of a secondary mutation that confers sensitivity to cell death, which drives the selection for specific compensatory mutations that confer defective growth control and cell death regulation, characteristic of human tumor cells.