C
Chetana Sachidanandan
Researcher at Institute of Genomics and Integrative Biology
Publications - 32
Citations - 2745
Chetana Sachidanandan is an academic researcher from Institute of Genomics and Integrative Biology. The author has contributed to research in topics: Zebrafish & Bone morphogenetic protein. The author has an hindex of 14, co-authored 28 publications receiving 2528 citations. Previous affiliations of Chetana Sachidanandan include Academy of Scientific and Innovative Research & Harvard University.
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Journal ArticleDOI
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Paul B. Yu,Charles C. Hong,Charles C. Hong,Chetana Sachidanandan,Jodie L. Babitt,Donna Y. Deng,Stefan A Hoyng,Herbert Y. Lin,Kenneth D. Bloch,Randall T. Peterson,Randall T. Peterson +10 more
TL;DR: The first known small-molecule inhibitor of BMP signaling-dorsomorphin is described, which was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish and found that dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation.
Journal ArticleDOI
BMP type I receptor inhibition reduces heterotopic ossification
Paul B. Yu,Donna Y. Deng,Carol S. Lai,Charles C. Hong,Gregory D. Cuny,Mary L. Bouxsein,Deborah W. Hong,Patrick M. McManus,Takenobu Katagiri,Chetana Sachidanandan,Nobuhiro Kamiya,Tomokazu Fukuda,Yuji Mishina,Yuji Mishina,Randall T. Peterson,Kenneth D. Bloch +15 more
TL;DR: The role of dysregulated ALK2 kinase activity in the pathogenesis of FOP is supported and small molecule inhibition of BMP type I receptor activity may be useful in treating FOP and heterotopic ossification syndromes associated with excessive BMP signaling.
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Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
Gregory D. Cuny,Paul B. Yu,Joydev K. Laha,Xuechao Xing,Ji-Feng Liu,Carol S. Lai,Donna Y. Deng,Chetana Sachidanandan,Kenneth D. Bloch,Randall T. Peterson +9 more
TL;DR: A structure-activity relationship study of dorsomorphin revealed that increased inhibitory activity could be accomplished by replacing the pendent 4-pyridine ring with 4-quinoline, and an optimized compound 13 demonstrated moderate pharmacokinetic characteristics following intraperitoneal administration in mice.
Journal ArticleDOI
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
Andrea U. Steinbicker,Chetana Sachidanandan,Ashley J. Vonner,Rushdia Z. Yusuf,Donna Y. Deng,Carol S. Lai,Kristen M. Rauwerdink,Julia C. Winn,Borja Saez,Colleen Cook,Brian A. Szekely,Cindy N. Roy,Jasbir Seehra,Gregory D. Cuny,David T. Scadden,Randall T. Peterson,Kenneth D. Bloch,Paul B. Yu +17 more
TL;DR: These studies support the concept that BMP and IL-6 act together to regulate iron homeostasis and suggest that inhibition of BMP signaling may be an effective strategy for the treatment of anemia of inflammation.
Journal ArticleDOI
lncRNome: a comprehensive knowledgebase of human long noncoding RNAs.
Deeksha Bhartiya,Koustav Pal,Sourav Ghosh,Shruti Kapoor,Saakshi Jalali,Bharat Panwar,Sakshi Jain,Satish Sati,Shantanu Sengupta,Chetana Sachidanandan,Gajendra P. S. Raghava,Sridhar Sivasubbu,Vinod Scaria +12 more
TL;DR: The lncRNome as mentioned in this paper is one of the largest and most comprehensive resources for long noncoding RNAs (lncRNAs) annotated with biologically relevant information.