Yuji Mishina

TL;DR: It is concluded that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of H SCs by regulating niche size.

TL;DR: The existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1.5 is reported, and differentiation was shown to occur roughly equally, with and without fusion to host cells.

TL;DR: It is shown that conditional inactivation of Bmpr1a in mice disturbs homeostasis of intestinal epithelial regeneration with an expansion of the stem and progenitor cell populations, eventually leading to intestinal polyposis resembling human juvenilePolyposis syndrome, and BMP signaling suppresses Wnt signaling to ensure a balanced control of stem cell self-renewal.

TL;DR: The role of dysregulated ALK2 kinase activity in the pathogenesis of FOP is supported and small molecule inhibition of BMP type I receptor activity may be useful in treating FOP and heterotopic ossification syndromes associated with excessive BMP signaling.

TL;DR: It is shown that Oct4 and Sox2 bind to a conserved promoter region of miR-302, a cluster of eight microRNAs expressed specifically in ESCs and pluripotent cells and represses the productive translation of an important G1 regulator, cyclin D1, in hESCs.