R
Randall T. Peterson
Researcher at University of Utah
Publications - 178
Citations - 20131
Randall T. Peterson is an academic researcher from University of Utah. The author has contributed to research in topics: Zebrafish & Hepcidin. The author has an hindex of 58, co-authored 168 publications receiving 17947 citations. Previous affiliations of Randall T. Peterson include Broad Institute & Brigham and Women's Hospital.
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Journal ArticleDOI
Efficient genome editing in zebrafish using a CRISPR-Cas system
Woong Y. Hwang,Yanfang Fu,Deepak Reyon,Morgan L. Maeder,Shengdar Q. Tsai,Jeffry D. Sander,Randall T. Peterson,Randall T. Peterson,Jing-Ruey J. Yeh,J. Keith Joung +9 more
TL;DR: It is shown that the CRISPR-Cas system functions in vivo to induce targeted genetic modifications in zebrafish embryos with efficiencies similar to those obtained using zinc finger nucleases and transcription activator-like effector nucleases.
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In vivo drug discovery in the zebrafish
TL;DR: By combining the scale and throughput of in vitro screens with the physiological complexity of animal studies, the zebrafish promises to contribute to several aspects of the drug development process, including target identification, disease modelling, lead discovery and toxicology.
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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Paul B. Yu,Charles C. Hong,Charles C. Hong,Chetana Sachidanandan,Jodie L. Babitt,Donna Y. Deng,Stefan A Hoyng,Herbert Y. Lin,Kenneth D. Bloch,Randall T. Peterson,Randall T. Peterson +10 more
TL;DR: The first known small-molecule inhibitor of BMP signaling-dorsomorphin is described, which was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish and found that dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation.
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Zebrafish as tools for drug discovery
TL;DR: The zebrafish has become a prominent vertebrate model for disease and has already contributed to several examples of successful phenotype-based drug discovery, but for it to become useful in drug development more broadly, key hurdles must be overcome.
Journal ArticleDOI
Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
Jason Rihel,David A. Prober,Anthony C. Arvanites,Kelvin Lam,Steven Zimmerman,Sumin Jang,Stephen J. Haggarty,Stephen J. Haggarty,David Kokel,Lee L. Rubin,Randall T. Peterson,Randall T. Peterson,Alexander F. Schier +12 more
TL;DR: The development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish are reported and it is found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors.