Cheuk T. Leung

TL;DR: F Fate-mapping analysis after olfactory neuroepithelium lesioning shows that mouse horizontal basal cells (HBCs) are competent to regenerate both neuronal and non-neuronal olfFactory neuroepIthelium lineages, which support a new model of adult neurogenesis in which distinct cell populations mediate normal neuronal turnover and neuronal replacement upon traumatic injury.

TL;DR: It is demonstrated that centrosome amplification, a structural alteration of the cytoskeleton, can promote features of malignant transformation.

TL;DR: The data show that the initial outgrowth of single oncogene-expressing cells from organized epithelial structures is a highly regulated process, and it is proposed that a cell translocation mechanism allows sporadic mutant cells to evade suppressive micro-environments and elicits clonal selection for survival and proliferative expansion outside the native niches of these cells.

TL;DR: It is shown that Ascl1, a bHLH (basic helix-loop-helix) transcription factor, transiently labels neuronal and oligodendrocyte precursors in the adult brain, and these AsCl1 defined progenitors mature with distinct dynamics in different brain regions.

TL;DR: This study provides the first global view of the architecture of an entire imprinted domain and provides candidate sequence elements for subsequent functional analyses.