R
Randall R. Reed
Researcher at Johns Hopkins University School of Medicine
Publications - 95
Citations - 16751
Randall R. Reed is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Olfactory epithelium & Olfactory system. The author has an hindex of 58, co-authored 94 publications receiving 16140 citations. Previous affiliations of Randall R. Reed include Howard Hughes Medical Institute & University of Maryland, Baltimore.
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Journal ArticleDOI
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.
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Golf: an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction
David T. Jones,Randall R. Reed +1 more
TL;DR: Evidence is presented suggesting that this G protein, termed Golf, mediates olfaction, and the expression of Golf alpha in S49 cyc- kin- cells, a line deficient in endogenous stimulatory G proteins, demonstrates its capacity to stimulate adenylate cyclase in a heterologous system.
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Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure.
John Krupinski,Françoise Coussen,Françoise Coussen,Heather A. Bakalyar,Wei-Jen Tang,Paul Feinstein,Kim Orth,Clive A. Slaughter,Randall R. Reed,Alfred G. Gilman +9 more
TL;DR: An unexpected topographical resemblance between adenylyl cyclase and various plasma membrane channels and transporters was observed, which suggests possible, unappreciated functions for this important enzyme.
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Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.
David T. Jones,Randall R. Reed +1 more
TL;DR: In olfactory tissue, G alpha s was the most abundant of these messages and in combination with the biochemical studies suggests that Galpha s is the G-protein component of the olfaction signal transduction cascade.
Journal ArticleDOI
Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection
TL;DR: The mammalian olfactory system may transduce odorant information via a G protein-mediated adenosine 3',5'-monophosphate (cAMP) cascade via a newly discovered adenylyl cyclase, termed type III, which has been cloned, and its expression was localized to o aroma neurons.