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Chia-Yi Cheng
Researcher at National Health Research Institutes
Publications - 4
Citations - 170
Chia-Yi Cheng is an academic researcher from National Health Research Institutes. The author has contributed to research in topics: Haematopoiesis & Chemokine receptor. The author has an hindex of 4, co-authored 4 publications receiving 155 citations. Previous affiliations of Chia-Yi Cheng include National Institutes of Health.
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Journal ArticleDOI
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
Yi-Hui Peng,Shau-Hua Ueng,Chen-Tso Tseng,Ming-Shiu Hung,Jen-Shin Song,Jian-Sung Wu,Fang-Yu Liao,Yu-Shiou Fan,Mine-Hsine Wu,Wen-Chi Hsiao,Ching-Cheng Hsueh,Shu Yu Lin,Chia-Yi Cheng,Chih-Hsiang Tu,Lung-Chun Lee,Ming-Fu Cheng,Kak-Shan Shia,Chuan Shih,Su-Ying Wu +18 more
TL;DR: This study presents the structure of IDO1 in complex with 24, a NLG919 analogue with potent activity and demonstrates that extensive hydrophobic interactions and the unique hydrogen bonding network contribute to the great potency of imidazoleisoindole derivatives.
Journal ArticleDOI
Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.
Chien Huang Wu,Chuan Jen Wang,Chun-Ping Chang,Yung-Chi Cheng,Jen Shin Song,Jiing Jyh Jan,Ming Chen Chou,Yi Yu Ke,Jing Ma,Ying Chieh Wong,Tsung Chih Hsieh,Yun Chen Tien,Elizabeth A. Gullen,Chen Fu Lo,Chia-Yi Cheng,Yu Wei Liu,Amit A. Sadani,Chia Hua Tsai,Hsin Pang Hsieh,Lun K. Tsou,Kak Shan Shia +20 more
TL;DR: A de novo hit-to-lead effort on the identification of subnanomolar purine-based CXCR4 antagonists against HIV-1 infection offers insight into the design of anti-HIV therapeutics devoid of major interference with SDF-1α function.
Journal ArticleDOI
Stem Cell Mobilizers Targeting Chemokine Receptor CXCR4: Renoprotective Application in Acute Kidney Injury
Chien-Huang Wu,Jen-Shin Song,Kuei-Hua Chang,Jiing-Jyh Jan,Chiung-Tong Chen,Ming-Chen Chou,Kai-Chia Yeh,Ying-Chieh Wong,Chen-Tso Tseng,Szu-Huei Wu,Ching-Fang Yeh,Chung-Yu Huang,Min-Hsien Wang,Amit A. Sadani,Chun-Ping Chang,Chia-Yi Cheng,Lun K. Tsou,Kak-Shan Shia +17 more
TL;DR: Treatment with compound 19 significantly lowered levels of blood urea nitrogen and serum creatinine in rats with renal ischemia-reperfusion injury, providing evidence for its therapeutic potential in preventing ischemic acute kidney injury.
Journal ArticleDOI
Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA Agents
Chia-Yi Cheng,Chun-Ping Chang,Tsai-Ling Lauderdale,Guann-Yi Yu,Jinq-Chyi Lee,Yi-Wun Jhang,Chien-Huang Wu,Yi-Yu Ke,Amit A. Sadani,Ching-Fang Yeh,I-Wen Huang,Yi-Ping Kuo,De-Jiun Tsai,Teng-Kuang Yeh,Chen-Tso Tseng,Jen-Shin Song,Yu-Wei Liu,Lun K. Tsou,Kak-Shan Shia +18 more
TL;DR: In a mouse model with lethal infection of MRSA, a 75% survival rate was observed after a single dose of compound 19 was intravenously administered at 20 mg/kg and the data underscore the importance of designed hybrid series for the development of new N-substituted carbazoles as potential anti-MRSA agents.