G
Guann-Yi Yu
Researcher at National Institutes of Health
Publications - 48
Citations - 6341
Guann-Yi Yu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 35 publications receiving 5508 citations. Previous affiliations of Guann-Yi Yu include National Cheng Kung University & University of California, San Diego.
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Journal ArticleDOI
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Sergei I. Grivennikov,Eliad Karin,Janoš Terzić,Janoš Terzić,Daniel Mucida,Guann-Yi Yu,Sivakumar Vallabhapurapu,Jürgen Scheller,Stefan Rose-John,Hilde Cheroutre,Lars Eckmann,Michael Karin +11 more
TL;DR: It is demonstrated that IL-6 is a critical tumor promoter during early CAC tumorigenesis and the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs.
Journal ArticleDOI
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
Eek Joong Park,Jun Hee Lee,Guann-Yi Yu,Guobin He,Syed Raza Ali,Ryan G. Holzer,Christoph H. Österreicher,Hiroyuki Takahashi,Michael Karin +8 more
TL;DR: It is demonstrated that either dietary or genetic obesity is a potent bona fide liver tumor promoter in mice and obesity-promoted HCC development was dependent on enhanced production of the tumor-promoting cytokines IL-6 and TNF, which cause hepatic inflammation and activation of the oncogenic transcription factor STAT3.
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Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Sergei I. Grivennikov,Kepeng Wang,Daniel Mucida,C. Andrew Stewart,Bernd Schnabl,Dominik Jauch,Koji Taniguchi,Guann-Yi Yu,Christoph H. Österreicher,Kenneth E. Hung,Christian Datz,Ying Feng,Eric R. Fearon,Mohamed Oukka,Lino Tessarollo,Vincenzo Coppola,Felix Yarovinsky,Hilde Cheroutre,Lars Eckmann,Giorgio Trinchieri,Michael Karin +20 more
TL;DR: It is proposed that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth.
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Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis
Toshiharu Sakurai,Guobin He,Atsushi Matsuzawa,Guann-Yi Yu,Shin Maeda,Gary Hardiman,Michael Karin +6 more
TL;DR: Hepatocyte-specific p38 alpha ablation enhanced ROS accumulation and liver damage, which were prevented upon administration of an antioxidant, and IL-1 alpha release by necrotic hepatocytes is therefore an important mediator of liver tumorigenesis.
Journal ArticleDOI
Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation
Guobin He,Guann-Yi Yu,Vladislav Temkin,Hisanobu Ogata,Christian Kuntzen,Toshiharu Sakurai,Toshiharu Sakurai,Wolfgang Sieghart,Markus Peck-Radosavljevic,Hyam L. Leffert,Michael Karin +10 more
TL;DR: A transplant system that allows initiated mouse hepatocytes to form hepatocellular carcinomas (HCC) in host liver after a long latency and deletion of IKKbeta long after initiation accelerated HCC development and enhanced proliferation of tumor initiating cells.