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Chido Mpamhanga
Researcher at Medical Research Council Technology
Publications - 5
Citations - 309
Chido Mpamhanga is an academic researcher from Medical Research Council Technology. The author has contributed to research in topics: Autophagosome & Kinase. The author has an hindex of 2, co-authored 5 publications receiving 237 citations.
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Journal ArticleDOI
Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy
Katy J. Petherick,Owen Conway,Chido Mpamhanga,Simon A. Osborne,Ahmad Kamal,Barbara Saxty,Ian G. Ganley +6 more
TL;DR: Two compounds, MRT67307 and MRT68921, potently inhibit ULK1 and ULK2 in vitro and block autophagy in cells, indicating a role for ULK 1 in the maturation of autophagosomes as well as initiation.
Journal ArticleDOI
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
Patrick J. McIntyre,P.M. Collins,Lukáš Vrzal,Kristian Birchall,Laurence H. Arnold,Chido Mpamhanga,P.J. Coombs,Selena G. Burgess,Mark W. Richards,Anja Winter,Vaclav Veverka,Frank von Delft,Frank von Delft,Andy Merritt,Richard Bayliss +14 more
TL;DR: The interface of the Aurora-A/TPX2 interaction is investigated using coprecipitation assays and isothermal titration calorimetry to quantify the energetic contribution of individual residues of TPX2, and arginine residues that communicate the phosphorylation of Thr288 to the TPx2 binding site are identified.
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Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer's disease.
Preeti Bakrania,Gareth Hall,Yvonne Bouter,Caroline Bouter,Nicola Beindorff,Richard Cowan,Sarah L. Davies,Jemma Price,Chido Mpamhanga,Elizabeth A. Love,David A. Matthews,Mark D. Carr,Thomas A. Bayer +12 more
TL;DR: In this paper, a pseudo β-hairpin structure was identified in the N-terminal region of Aβ and showed that this underpins its unique binding properties, which offers new routes for active and passive immunisation against Alzheimer's disease.
Journal ArticleDOI
Phenotypic high-content screen measuring clearance of tdp - 43 aggregates
Emilie A. Bureau,Chido Mpamhanga,Laura De Conti,Paul D. Wright,Lucia Cragnaz,David Tickle,Catherine A. Kettleborough,Marco Baralle,David Reynolds,Janet Brownlees +9 more
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Identification of potent inhibitors of microtubule affinity regulating kinase for inhibition of tau hyperphosphorylation
Alison Levy,Michelle Newman,Janet Brownlees,Denise J. Harding,Joanne Osborne,Stephen John Lewis,Kevin J. Gillen,Gareth Hall,Chido Mpamhanga,Andy Merritt,Debra L. Taylor,Ed Mclver +11 more
TL;DR: The aim was to identify a potent and selective ATP-competitive MARK inhibitor that could be used for ‘proof of concept’ studies in transgenic mice expressing human tau and potentially as a starting point for a drug development program.