C
Ching-Tsan Huang
Researcher at National Taiwan University
Publications - 42
Citations - 2800
Ching-Tsan Huang is an academic researcher from National Taiwan University. The author has contributed to research in topics: Biofilm & Pichia pastoris. The author has an hindex of 23, co-authored 41 publications receiving 2654 citations. Previous affiliations of Ching-Tsan Huang include Duke University & Montana State University.
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Journal ArticleDOI
Spatial physiological heterogeneity in Pseudomonas aeruginosa biofilm is determined by oxygen availability.
Karen D. Xu,Philip S. Stewart,Philip S. Stewart,Fuhu Xia,Ching-Tsan Huang,Gordon A. McFeters +5 more
TL;DR: Experiments revealed marked spatial physiological heterogeneity within P. aeruginosa biofilms in which active protein synthesis was restricted by oxygen availability to the upper 30 μm of the biofilm, which has implications for microbial ecology and for understanding the reduced susceptibilities of biofilm to antimicrobial agents.
Journal ArticleDOI
Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide
Daniel J. Hassett,Ju-Fang Ma,James Elkins,James Elkins,Timothy R. McDermott,Timothy R. McDermott,Urs A. Ochsner,Susan E. H. West,Ching-Tsan Huang,Jessie Fredericks,Scott Burnett,Philip S. Stewart,Gordon A. McFeters,Luciano Passador,Barbara H. Iglewski +14 more
TL;DR: Evidence of QS control of genes essential for relieving oxidative stress is provided, as PAI mutant biofilm sensitivity appeared not to be incrementally correlated to catalase levels.
Journal ArticleDOI
Nonuniform spatial patterns of respiratory activity within biofilms during disinfection.
TL;DR: Epifluorescence micrographs of frozen biofilm cross sections clearly revealed gradients of respiratory activity within biofilms in response to monochloramine treatment, quantified by calculating the ratio of CTC and DAPI intensities measured by image analysis.
Journal ArticleDOI
Effects of quorum-sensing deficiency on Pseudomonas aeruginosa biofilm formation and antibiotic resistance
Pei-Ching Shih,Ching-Tsan Huang +1 more
TL;DR: Variations in biofilm formation by, and antibiotic resistance of, Pseudomonas aeruginosa PAO1 and the quorum-sensing-deficient mutants PDO100, JP1, JP2 and JP2 were studied.
Journal ArticleDOI
Spatial variations in growth rate within Klebsiella pneumoniae colonies and biofilm
TL;DR: The use of acridine orange to visualize and quantify spatial variations in growth rate within Klebsiella pneumoniae colonies and biofilm suggests that it is best applied in single species systems and that the results should be regarded as qualitative in nature.