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Chloe L. Thio
Researcher at Johns Hopkins University
Publications - 178
Citations - 12033
Chloe L. Thio is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 53, co-authored 169 publications receiving 11280 citations. Previous affiliations of Chloe L. Thio include Johns Hopkins University School of Medicine & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
David L. Thomas,Chloe L. Thio,Maureen P. Martin,Ying Qi,Dongliang Ge,Colm O'hUigin,Judith R. Kidd,Kenneth K. Kidd,Salim I. Khakoo,Graeme J.M. Alexander,James J. Goedert,Gregory D. Kirk,Sharyne M. Donfield,Hugo R. Rosen,Leslie H. Tobler,Michael P. Busch,John G. McHutchison,David Goldstein,Mary Carrington +18 more
TL;DR: It is shown that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry, the strongest and most significant genetic effect associated with natural clearance ofHCV.
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HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
Salim I. Khakoo,Chloe L. Thio,Maureen P. Martin,Collin Brooks,Xiaojiang Gao,Jacquie Astemborski,Jie Cheng,James J. Goedert,David Vlahov,Margaret W. Hilgartner,Steven T. Cox,Ann Margeret Little,Graeme J.M. Alexander,Matthew E. Cramp,Stephen J. O'Brien,William Rosenberg,David L. Thomas,Mary Carrington +17 more
TL;DR: The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
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HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Chloe L. Thio,Eric C. Seaberg,Richard L. Skolasky,John P. Phair,Barbara R. Visscher,Alvaro Muñoz,David L. Thomas +6 more
TL;DR: Individuals coinfected with HIV-1 and HBV, especially those with low CD4+ nadir counts, are at increased risk for liver-related mortality, underscoring the importance of prevention, identification, and comprehensive management of hepatitis B in people infected withAIDS.
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Clinical implications of HIV and hepatitis B co-infection in Asia and Africa.
TL;DR: In this paper, the authors discuss the epidemiology, natural history, pathogenesis, and management of HIV/HBV co-infection from areas with high chronic hepatitis B prevalence.
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Hepatitis B and human immunodeficiency virus coinfection
TL;DR: The management of hepatitis B in HIV infection is complicated by the dual activity of several nucleoside analogs, the more rapid development of lamivudine‐resistant HBV in patients who are HIV‐positive, and the paucity of studies.