Y
Ying Qi
Researcher at Leidos
Publications - 13
Citations - 3208
Ying Qi is an academic researcher from Leidos. The author has contributed to research in topics: Human leukocyte antigen & Receptor. The author has an hindex of 11, co-authored 13 publications receiving 3000 citations. Previous affiliations of Ying Qi include Science Applications International Corporation & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
David L. Thomas,Chloe L. Thio,Maureen P. Martin,Ying Qi,Dongliang Ge,Colm O'hUigin,Judith R. Kidd,Kenneth K. Kidd,Salim I. Khakoo,Graeme J.M. Alexander,James J. Goedert,Gregory D. Kirk,Sharyne M. Donfield,Hugo R. Rosen,Leslie H. Tobler,Michael P. Busch,John G. McHutchison,David Goldstein,Mary Carrington +18 more
TL;DR: It is shown that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry, the strongest and most significant genetic effect associated with natural clearance ofHCV.
Journal ArticleDOI
Influence of HLA-C Expression Level on HIV Control
Richard Apps,Richard Apps,Ying Qi,Ying Qi,Jonathan M. Carlson,Haoyan Chen,Haoyan Chen,Xiaojiang Gao,Xiaojiang Gao,Rasmi Thomas,Yuko Yuki,Yuko Yuki,Greg Q. Del Prete,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder,Zabrina L. Brumme,Chanson J. Brumme,Mina John,Simon Mallal,George W. Nelson,Ronald J. Bosch,David Heckerman,Judy L. Stein,Kelly A. Soderberg,M. Anthony Moody,Thomas N. Denny,Xue Zeng,Xue Zeng,Jingyuan Fang,Ashley Moffett,Jeffrey D. Lifson,James J. Goedert,Susan Buchbinder,Gregory D. Kirk,Jacques Fellay,Paul J. McLaren,Steven G. Deeks,Florencia Pereyra,Bruce D. Walker,Nelson L. Michael,Amy C. Weintrob,Steven M. Wolinsky,Wilson Liao,Mary Carrington,Mary Carrington +45 more
TL;DR: It is demonstrated that increasing surface expression of HLA-C is associated with reduced viral load and reduced rate of progression to low CD4+ T cell counts in African and European Americans.
Journal ArticleDOI
Differential microRNA regulation of HLA-C expression and its association with HIV control
Smita Kulkarni,Ram Savan,Ying Qi,Ying Qi,Xiaojiang Gao,Xiaojiang Gao,Yuko Yuki,Yuko Yuki,Sara Bass,Maureen P. Martin,Maureen P. Martin,Peter W. Hunt,Steven G. Deeks,Amalio Telenti,Florencia Pereyra,David Goldstein,Steven M. Wolinsky,Bruce D. Walker,Howard A. Young,Mary Carrington,Mary Carrington +20 more
TL;DR: It is shown that variation within the 3′ untranslated region (UTR) of HLA-C regulates binding of the microRNA hsa-miR-148 to its target site, resulting in relatively low surface expression of alleles that bind this microRNA and high expression of Hla-C allele that escape post-transcriptional regulation.
Journal ArticleDOI
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
Veron Ramsuran,Vivek Naranbhai,Amir Horowitz,Ying Qi,Maureen P. Martin,Yuko Yuki,Xiaojiang Gao,Victoria Walker-Sperling,Gregory Q. Del Prete,Douglas K. Schneider,Jeffrey D. Lifson,Jacques Fellay,Steven G. Deeks,Jeffrey N. Martin,James J. Goedert,Steven M. Wolinsky,Nelson L. Michael,Gregory D. Kirk,Susan Buchbinder,David W. Haas,Thumbi Ndung'u,Philip J. R. Goulder,Peter Parham,Bruce D. Walker,Jonathan M. Carlson,Mary Carrington,Mary Carrington +26 more
TL;DR: Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV- infected targets.
Journal ArticleDOI
Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease
Smita Kulkarni,Ying Qi,Colm O'hUigin,Florencia Pereyra,Veron Ramsuran,Paul J. McLaren,Jacques Fellay,George W. Nelson,Haoyan Chen,Haoyan Chen,Wilson Liao,Sara Bass,Richard Apps,Xiaojiang Gao,Yuko Yuki,Alexandra Lied,Anuradha Ganesan,Peter W. Hunt,Steven G. Deeks,Steven M. Wolinsky,Bruce D. Walker,Mary Carrington +21 more
TL;DR: It is demonstrated that a MIR148A insertion/deletion polymorphism associates with its own expression levels, affecting the extent to which HLA-C is down-regulated, the level of HIV control, and the risk of Crohn disease only among those carrying an intact miR-148a binding site in the HLA -C 3′UTR.