L
Leslie H. Tobler
Researcher at Systems Research Institute
Publications - 84
Citations - 6838
Leslie H. Tobler is an academic researcher from Systems Research Institute. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 39, co-authored 84 publications receiving 6575 citations. Previous affiliations of Leslie H. Tobler include University of Cincinnati Academic Health Center & University of California, San Francisco.
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Journal ArticleDOI
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
David L. Thomas,Chloe L. Thio,Maureen P. Martin,Ying Qi,Dongliang Ge,Colm O'hUigin,Judith R. Kidd,Kenneth K. Kidd,Salim I. Khakoo,Graeme J.M. Alexander,James J. Goedert,Gregory D. Kirk,Sharyne M. Donfield,Hugo R. Rosen,Leslie H. Tobler,Michael P. Busch,John G. McHutchison,David Goldstein,Mary Carrington +18 more
TL;DR: It is shown that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry, the strongest and most significant genetic effect associated with natural clearance ofHCV.
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Hepatitis C Virus Seroconversion among Young Injection Drug Users: Relationships and Risks
Judith A. Hahn,Kimberly Page-Shafer,Paula J. Lum,Philippe Bourgois,Ellen Stein,Jennifer L. Evans,Michael P. Busch,Leslie H. Tobler,Bruce Phelps,Andrew R. Moss +9 more
TL;DR: Ubiquitous behaviors among young IDUs, such as the forming of injecting or sexual partnerships and consequent sharing of needles and drug preparation equipment, are risk factors for HCV.
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Acute Hepatitis C Virus Infection in Young Adult Injection Drug Users: A Prospective Study of Incident Infection, Resolution, and Reinfection
Kimberly Page,Judith A. Hahn,Jennifer L. Evans,Stephen Shiboski,Paula J. Lum,Eric Delwart,Leslie H. Tobler,William Andrews,Lia Avanesyan,Stewart Cooper,Michael P. Busch,Michael P. Busch +11 more
TL;DR: In this large sample of young IDUs, females show demonstrative differences in their rates of viral clearance and kinetics of early viral decline, and reclearance suggest possible protection against persistent infection.
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Tregs control the development of symptomatic West Nile virus infection in humans and mice
Marion C. Lanteri,Katie M. O'Brien,Whitney E. Purtha,Mark J. Cameron,Jennifer M. Lund,Rachel E. Owen,John W. Heitman,Brian Custer,Dale F. Hirschkorn,Leslie H. Tobler,Nancy Kiely,Harry E. Prince,Lishomwa C. Ndhlovu,Douglas F. Nixon,Hany Kamel,David J. Kelvin,Michael P. Busch,Alexander Y. Rudensky,Michael S. Diamond,Philip J. Norris +19 more
TL;DR: It is suggested that higher levels of peripheral Tregs after infection protect against severe WNV disease in immunocompetent animals and humans.
Journal ArticleDOI
Iron deficiency in blood donors: the REDS-II Donor Iron Status Evaluation (RISE) study.
Ritchard G. Cable,Simone A. Glynn,Joseph E. Kiss,Alan E. Mast,Whitney R. Steele,Edward L. Murphy,David J. Wright,Ronald A. Sacher,Jerry L. Gottschall,Leslie H. Tobler,Toby L. Simon +10 more
TL;DR: The effects of blood donation intensity on iron and hemoglobin (Hb) in a prospective study is evaluated and it is shown that blood donors are at risk of iron deficiency.