C
Chris TenHoor
Researcher at Exa Corporation
Publications - 4
Citations - 434
Chris TenHoor is an academic researcher from Exa Corporation. The author has contributed to research in topics: Matrix metalloproteinase & Pharmacodynamics. The author has an hindex of 4, co-authored 4 publications receiving 387 citations.
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Journal ArticleDOI
Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis.
Laetitia Devy,Lili Huang,Laurent Naa,Niranjan Yanamandra,Henk Pieters,Nicolas Frans,Edward F. Chang,Qingfeng Tao,Marc Vanhove,Annabelle Lejeune,Reinoud van Gool,Daniel J. Sexton,Guannan Kuang,Douglas Rank,Shannon Hogan,Csaba Pazmany,Yu Lu Ma,Sonia Schoonbroodt,Andrew E. Nixon,Robert Charles Ladner,Rene Hoet,Paula Henderikx,Chris TenHoor,Shafaat A. Rabbani,Maria-Luisa Valentino,Clive R. Wood,Daniel T. Dransfield +26 more
TL;DR: In this paper, the authors used a highly selective fully human MMP-14 inhibitory antibody discovered using phage display technology, which blocked proMMP-2 processing on tumor and endothelial cells, inhibited angiogenesis, and slowed tumor progression and formation of metastatic lesions.
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A phase 1 study investigating DX-2930 in healthy subjects
Yung Chyung,Bradley Vince,Ryan Iarrobino,Daniel J. Sexton,Jon A. Kenniston,Ryan Faucette,Chris TenHoor,Leslie E. Stolz,Chris Stevens,Joseph C. Biedenkapp,Burt Adelman +10 more
TL;DR: Pharmacokinetic and pharmacodynamic data provide evidence for a long-acting biological effect relevant to long-term prophylaxis for hereditary angioedema with C1-inhibitor deficiency, and dose- and time-dependent inhibition of plasma kallikrein with evidence of sustained bioactivity consistent with the pharmacokinetics profile.
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Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates
Andrew E. Nixon,Jie Chen,Daniel J. Sexton,Arumugam Muruganandam,Alan J. Bitonti,Jennifer A. Dumont,Malini Viswanathan,Diana Martik,Dina Wassaf,Adam R. Mezo,Clive R. Wood,Joseph C. Biedenkapp,Chris TenHoor +12 more
TL;DR: The discovery and preclinical evaluation of fully human monoclonal IgG antibody inhibitors of FcRn are described and important preclinical proof of concept data is provided in support of F cRn antagonism as a novel approach to the treatment of antibody-mediated autoimmune diseases.
Journal ArticleDOI
Comparison Of Plasma Kallikrein Inhibition By The Endogenous C1-Inhibitor Versus DX-2930, a Monoclonal Antibody Inhibitor
Daniel J. Sexton,Jon A. Kenniston,Ryan Faucette,Andrew E. Nixon,Chris TenHoor,Yung Chyung,Burt Adelman +6 more
TL;DR: The requirement for super-stoichiometric amounts of endogenous C1-INH to adequately regulate pKal activity is investigated, which is likely to be a physiologically relevant form of the enzyme and may provide an explanation for attack localization in HAE.