E
Edward F. Chang
Researcher at University of California, San Francisco
Publications - 469
Citations - 28836
Edward F. Chang is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medicine & Epilepsy. The author has an hindex of 72, co-authored 363 publications receiving 21922 citations. Previous affiliations of Edward F. Chang include University of Texas MD Anderson Cancer Center & University of California, Berkeley.
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Journal ArticleDOI
Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.
Ye Zhang,Steven A. Sloan,Laura E. Clarke,Christine Caneda,Colton A. Plaza,Paul D. Blumenthal,Hannes Vogel,Gary K. Steinberg,Michael S. B. Edwards,Gordon Li,John A. Duncan,Samuel H. Cheshier,Lawrence M. Shuer,Edward F. Chang,Gerald A. Grant,Melanie Hayden Gephart,Ben A. Barres +16 more
TL;DR: The development of an immunopanning method to acutely purify astrocytes from fetal, juvenile, and adult human brains and to maintain these cells in serum-free cultures is reported, finding that human astroCytes have abilities similar to those of murine astroicytes in promoting neuronal survival, inducing functional synapse formation, and engulfing synaptosomes.
Journal ArticleDOI
New tools for studying microglia in the mouse and human CNS.
Mariko L. Bennett,F. Chris Bennett,Shane A. Liddelow,Shane A. Liddelow,Bahareh Ajami,Jennifer L. Zamanian,Nathaniel B. Fernhoff,Sara B. Mulinyawe,Christopher J. Bohlen,Aykezar Adil,Andrew Tucker,Irving L. Weissman,Edward F. Chang,Gordon Li,Gerald A. Grant,Melanie Hayden Gephart,Ben A. Barres +16 more
TL;DR: Transmembrane protein 119 (Tmem119), a cell-surface protein of unknown function, is identified as a highly expressed microglia-specific marker in both mouse and human, which will greatly facilitate understanding of microglial function in health and disease.
Journal ArticleDOI
Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas
Justin S. Smith,Edward F. Chang,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Soonmee Cha,Tarik Tihan,Scott R. VandenBerg,Michael W. McDermott,Mitchel S. Berger +9 more
TL;DR: Improved outcome among adult patients with hemispheric LGG is predicted by greater EOR, and progression-free survival was predicted by log preoperative tumor volume and postoperative volume.
Journal ArticleDOI
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Shawn F. Sorrells,Mercedes F. Paredes,Arantxa Cebrián-Silla,Kadellyn Sandoval,Dashi Qi,Kevin W. Kelley,David James,Simone Mayer,Julia W. Chang,Kurtis I. Auguste,Edward F. Chang,Antonio Gutierrez,Arnold R. Kriegstein,Gary W. Mathern,Michael C. Oldham,Eric J. Huang,José Manuel García-Verdugo,Zhengang Yang,Arturo Alvarez-Buylla +18 more
TL;DR: It is shown that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development, and that neurogenesis in the dentate gyrus does not continue, or is extremely rare, in adult humans.
Journal ArticleDOI
Selective cortical representation of attended speaker in multi-talker speech perception
Nima Mesgarani,Edward F. Chang +1 more
TL;DR: It is demonstrated that population responses in non-primary human auditory cortex encode critical features of attended speech: speech spectrograms reconstructed based on cortical responses to the mixture of speakers reveal the salient spectral and temporal features of the attended speaker, as if subjects were listening to that speaker alone.