C
Christi S. Kleoudis
Researcher at Research Triangle Park
Publications - 14
Citations - 718
Christi S. Kleoudis is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Placebo & Alvimopan. The author has an hindex of 7, co-authored 12 publications receiving 694 citations.
Papers
More filters
Journal ArticleDOI
Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease
William J. Sandborn,William J. Tremaine,Douglas C. Wolf,Stephan R. Targan,Charles A. Sninsky,Lloyd R. Sutherland,Stephen B. Hanauer,John W.D. McDonald,Brian G. Feagan,Richard N. Fedorak,Kim L. Isaacs,M.Gennette Pike,Dennis C. Mays,James J. Lipsky,Susan Gordon,Christi S. Kleoudis,Robert H. Murdock +16 more
TL;DR: A loading dose does not decrease the time to response in patients with steroid-treated Crohn's disease beginning azathioprine therapy, and steady state of erythrocyte 6-thioguanine nucleotide and complete response occurred earlier than previously reported.
Journal ArticleDOI
Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain.
Lynn R. Webster,Jan Peter Jansen,John F. Peppin,Ben Lasko,Gordon Irving,Bart Morlion,Jerry Snidow,Amy Pierce,E. Mortensen,Christi S. Kleoudis,Eric G. Carter +10 more
TL;DR: Increased SBM frequency and additional treatment effects, including improvements in symptoms such as straining, stool consistency, incomplete evacuation, abdominal bloating/discomfort, and decreased appetite, were sustained over 6 weeks.
Journal ArticleDOI
A dose-ranging, placebo-controlled, randomized trial of alosetron in patients with functional dyspepsia.
Nicholas J. Talley,S van Zanten,L. R. Saez,George E. Dukes,Teresa B. Perschy,Mark R. Heath,Christi S. Kleoudis,Allen W. Mangel +7 more
TL;DR: Functional dyspepsia is characterized by upper abdominal pain or discomfort that is accompanied by vomiting, diarrhoea, or constipation.
Journal ArticleDOI
Heartburn requiring frequent antacid use may indicate significant illness.
Malcolm Robinson,David L. Earnest,Sheila Rodriguez-Stanley,Beverley Greenwood-Van Meerveld,Philip E. Jaffe,Marianne T. Silver,Christi S. Kleoudis,Lynn E. Wilson,Robert H. Murdock +8 more
TL;DR: Chronic heartburn can reflect a wide range of diagnostic findings, including important underlying pathological features, and may warrant a full medical examination to detect such abnormal conditions and to permit selection of appropriate therapy.
Journal ArticleDOI
A Randomized, Placebo-Controlled Phase 3 Trial (Study SB-767905/013) of Alvimopan for Opioid-Induced Bowel Dysfunction in Patients With Non-Cancer Pain
Gordon Irving,Janos Pénzes,Brian Ramjattan,Michael J. Cousins,Richard Rauck,Egilius L.H. Spierings,Christi S. Kleoudis,Jerry Snidow,Amy Pierce,John I. Wurzelmann,E. Mortensen +10 more
TL;DR: Although the primary endpoint was not met in this study, the magnitude of alvimopan-induced improvements versus baseline, together with previous study results, suggest that a PAM-OR antagonist has the potential to improve OIC.