J
John F. Peppin
Researcher at University of California, San Diego
Publications - 10
Citations - 673
John F. Peppin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Neuropathic pain & Chronic pain. The author has an hindex of 7, co-authored 8 publications receiving 607 citations.
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Journal ArticleDOI
An Analysis of the Root Causes for Opioid-Related Overdose Deaths in the United States
Lynn R. Webster,Susan Cochella,Nabarun Dasgupta,Keri L. Fakata,Perry G. Fine,Scott M. Fishman,Todd C. Grey,Erin M. Johnson,Lewis Lee,Steven D. Passik,John F. Peppin,Christina A. Porucznik,Albert Ray,Sidney H. Schnoll,Richard L. Stieg,Wayne W. Wakeland +15 more
TL;DR: Clinical strategies to reduce opioid-related mortality should be empirically tested, should not reduce access to needed therapies, should address risk from methadone as well as other opioids, and should be incorporated into any risk evaluation and mitigation strategies enacted by regulators.
Journal ArticleDOI
Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain.
Lynn R. Webster,Jan Peter Jansen,John F. Peppin,Ben Lasko,Gordon Irving,Bart Morlion,Jerry Snidow,Amy Pierce,E. Mortensen,Christi S. Kleoudis,Eric G. Carter +10 more
TL;DR: Increased SBM frequency and additional treatment effects, including improvements in symptoms such as straining, stool consistency, incomplete evacuation, abdominal bloating/discomfort, and decreased appetite, were sustained over 6 weeks.
Journal ArticleDOI
Recommendations for urine drug monitoring as a component of opioid therapy in the treatment of chronic pain.
John F. Peppin,Steven D. Passik,Joseph E. Couto,Perry G. Fine,Paul J. Christo,Charles Argoff,Gerald M. Aronoff,Daniel S. Bennett,Martin D. Cheatle,Kieran A. Slevin,Neil I. Goldfarb +10 more
TL;DR: The recommendations are meant to provide a framework for standardizing practices for UDM in the treatment of chronic pain, and to serve as a catalyst to advance research that quantifies the effects of UDM on opioid therapy management and patient outcomes.
Journal ArticleDOI
Pain Pathways and Nervous System Plasticity: Learning and Memory in Pain.
Bill McCarberg,John F. Peppin +1 more
TL;DR: The chronification of pain can be conceptualized as activity-induced plasticity of the limbic-cortical circuitry resulting in reorganization of the neocortex.
Journal ArticleDOI
Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic pain.
Lynn R. Webster,John F. Peppin,Frederick T. Murphy,Biao Lu,Jeffrey Tobias,Geertrui F. Vanhove +5 more
TL;DR: NGX-4010 in conjunction with any of the three topical anesthetics tested was generally safe and well tolerated and reduced pain over a 12-week period in patients with PDN and PHN.