Christian A. M. Wilson

TL;DR: It is proposed that the heat released during catalysis generates an asymmetric pressure wave that results in a differential stress at the protein–solvent interface that transiently displaces the centre-of-mass of the enzyme (chemoacoustic effect).

TL;DR: In this article, the authors used single-molecule fluorescence correlation spectroscopy to show that for enzymes that catalyse chemical reactions with large reaction enthalpies, the heat released at the protein's active site during catalysis transiently displaces the protein center-of-mass, essentially giving rise to a recoil effect that propels the enzyme.

TL;DR: The focus of this review is on optical tweezer experiments, which can be used to apply and measure mechanical forces in molecular systems, and parameters such as kinetic constants, affinity values, and distance to the transition state Δx≠ can be obtained.

TL;DR: In this paper , the authors showed that VEGFR2 is necessary for Histatin-1-induced endothelial cell migration, as shown by both pharmacological inhibition studies and siRNA-mediated ablation of vascular endothelial growth factor receptor 2.

TL;DR: In this paper , the authors explore the temperature dependence of the thermodynamic and kinetic parameters of the single-molecule level of Methanocaldococcus jannaschii.