C
Christian Cobbold
Researcher at Griffith University
Publications - 26
Citations - 1545
Christian Cobbold is an academic researcher from Griffith University. The author has contributed to research in topics: Endoplasmic reticulum & Capsid. The author has an hindex of 16, co-authored 26 publications receiving 1435 citations. Previous affiliations of Christian Cobbold include University of Oxford & Cardiff University.
Papers
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Journal ArticleDOI
The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans
Christine A. Wells,Judith Salvage-Jones,Xin Li,Kelly J Hitchens,Suzanne Butcher,Rachael Z. Murray,Anthony G Beckhouse,Yu-Lan-Sandra Lo,Silvia Manzanero,Christian Cobbold,Kate Schroder,Bo Ma,Sally Orr,Lauren Stewart,Daniel Lebus,Peter Sobieszczuk,David A. Hume,Jennifer L. Stow,Helen Blanchard,Robert B. Ashman +19 more
TL;DR: Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans.
The Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicans
Christine A. Wells,Judith Salvage-Jones,Xin Li,Kelly J Hitchens,Suzanne Butcher,Rachael Z. Murray,Anthony G Beckhouse,Yu-Lan-Sandra Lo,Silvia Manzanero,Christian Cobbold,Kate Schroder,Bo Ma,Sally Orr,Lauren Stewart,Daniel Lebus,Peter Sobieszczuk,David A. Hume,Jennifer L. Stow,Helen Blanchard,Robert B. Ashman +19 more
TL;DR: In this paper, the c-type lectin Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli.
Journal ArticleDOI
LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome
Emmanuelle Bitoun,Alessia Micheloni,Laurence Lamant,Chrystelle Bonnart,Alessandro Tartaglia-Polcini,Christian Cobbold,Talal Al Saati,Feliciana Mariotti,Juliette Mazereeuw-Hautier,Franck Boralevi,Daniel Hohl,John I. Harper,Christine Bodemer,Marina D'Alessio,Alain Hovnanian +14 more
TL;DR: LEKTI is a marker of epithelial differentiation, strongly expressed in the granular and uppermost spinous layers of the epidermis, and in differentiated layers of stratified epithelia, and the identification of novel processed forms of LEKTI provides the basis for future functional and structural studies of fragments with physiological relevance.
Journal ArticleDOI
Involvement of the endoplasmic reticulum in the assembly and envelopment of African swine fever virus.
TL;DR: Evidence is provided for the binding of ASF virus structural proteins to a specific membrane compartment and implicate a role for the ER in the assembly and envelopment of AsF virus.
Book ChapterDOI
Cell Biology of Membrane Trafficking in Human Disease
Gareth J. Howell,Zoe G. Holloway,Christian Cobbold,Anthony P. Monaco,Sreenivasan Ponnambalam +4 more
TL;DR: This review focuses on human genetic defects and molecular mechanisms that underlie eukaryote exocytosis and endocytotic and current and future prospects for alleviation of a variety of human diseases.