H
Helen Blanchard
Researcher at Griffith University
Publications - 69
Citations - 3248
Helen Blanchard is an academic researcher from Griffith University. The author has contributed to research in topics: Galectin & Rotavirus. The author has an hindex of 29, co-authored 66 publications receiving 2921 citations. Previous affiliations of Helen Blanchard include University of Alberta & University of Queensland.
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Journal ArticleDOI
The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans
Christine A. Wells,Judith Salvage-Jones,Xin Li,Kelly J Hitchens,Suzanne Butcher,Rachael Z. Murray,Anthony G Beckhouse,Yu-Lan-Sandra Lo,Silvia Manzanero,Christian Cobbold,Kate Schroder,Bo Ma,Sally Orr,Lauren Stewart,Daniel Lebus,Peter Sobieszczuk,David A. Hume,Jennifer L. Stow,Helen Blanchard,Robert B. Ashman +19 more
TL;DR: Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans.
The Macrophage Inducible c-type lectin, Mincle, is an essential component of the innate-immune response to Candida albicans
Christine A. Wells,Judith Salvage-Jones,Xin Li,Kelly J Hitchens,Suzanne Butcher,Rachael Z. Murray,Anthony G Beckhouse,Yu-Lan-Sandra Lo,Silvia Manzanero,Christian Cobbold,Kate Schroder,Bo Ma,Sally Orr,Lauren Stewart,Daniel Lebus,Peter Sobieszczuk,David A. Hume,Jennifer L. Stow,Helen Blanchard,Robert B. Ashman +19 more
TL;DR: In this paper, the c-type lectin Mincle was observed to localise in the phagocytic cup of macrophages in response to a range of stimuli.
Journal ArticleDOI
Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes.
Helen Blanchard,Pawel Grochulski,Y. Li,J. S. C. Arthur,Peter L. Davies,John S. Elce,Miroslaw Cygler +6 more
TL;DR: A first view of the calcium-induced conformational changes is given, and consequently an insight into the mechanism of calcium induced activation in calpain is gained.
Journal ArticleDOI
Sialic acid dependence in rotavirus host cell invasion
Thomas Haselhorst,Fiona E. Fleming,Jeffrey Clifford Dyason,Regan David Hartnell,Xing Yu,Gavan Holloway,Kim Santegoets,Milton J. Kiefel,Helen Blanchard,Barbara S. Coulson,Mark von Itzstein +10 more
TL;DR: It is shown that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses and the glycans of gangliosides G(M1) and G(D1a) are determined by NMR spectroscopy and molecular modeling.
Journal ArticleDOI
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis
Helen Blanchard,Lalitha Kodandapani,Peer R. E. Mittl,Stefania Di Marco,Joseph F. Krebs,Joe C. Wu,Kevin J. Tomaselli,Markus G. Grütter +7 more
TL;DR: The crystal structure of a complex of the activated human caspase-8 (proteolytic domain) with the irreversible peptidic inhibitor Z-Glu-Val-Asp-dichloromethylketone is reported, which is the firstructure of a representative of the long prodomain initiator caspases and of the group III substrate specificity class.