Christian Hametner

TL;DR: The in vivo metabolism of DON in humans was investigated and two closely eluting DON-GlcA's in naturally contaminated urine samples for the first time were determined and tentatively identified DON-15-glucuronide as a major DON metabolite in human urine based on the analysis of these samples.

TL;DR: The results indicate that barley exhibits multiple defense mechanisms against trichothecenes, and evidence for nonenzymatic formation of DON-glutathione adducts in vitro was found using both liquid chromatography-mass spectrometry and nuclear magnetic resonance analysis, indicating that the formation of Don-glUTathione conjugates in vivo may reduce the impact of trichohcenes.

TL;DR: In rice cultures, a new trichothecene mycotoxin (named NX‐2) was characterized by liquid chromatography‐tandem mass spectrometry and genetic analysis revealed a different TRI 1 allele in the N‐isolates, which was verified to be responsible for the difference in hydroxylation at C‐8.

TL;DR: It is concluded that the developed LC/MS/MS method is well suited to quantify multiple mycotoxin biomarkers in human urine down to the sub-ppb range within 18 min and without any prior cleanup.

TL;DR: LC-NMR analysis of photocured mixtures containing 1 and the sterically hindered acrylate 3,3-dimethyl-2-methylenebutanoate reveals that the products formed in the course of a polymerization are consistent with the intermediates established at short time scales.