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Christian Junghanss
Researcher at University of Rostock
Publications - 175
Citations - 3011
Christian Junghanss is an academic researcher from University of Rostock. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 20, co-authored 144 publications receiving 2514 citations.
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CHARTA: FOLFOX+bevacizumab +/- irinotecan in advanced colorectal cancer (CRC)—Final results of the randomized phase II trial of the AIO (KRK 0209).
Hans-Joachim Schmoll,Benjamin Garlipp,Christian Junghanss,Malte Leithaeuser,Arndt Vogel,Michael Schaefers,Ulrich Kaiser,Heinz-Gert Hoeffkes,Axel Florschütz,Jörn Rüssel,Stephan Kanzler,Thomas Edelmann,Helmut Forstbauer,Thomas Goehler,Carla Hannig,Bert Hildebrandt,Jörg Steighardt,Fabian Maximilian Meinert,Franziska Cygon,Alexander Stein +19 more
TL;DR: Primary endpoint was met: significa... secondary EP: significant improvement of PFS-rate at 9 months, and the same 4-drug-regimen vs. FOLFOX+Bev was superior to FOLFIRI-Bev.
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Unraveling the Heterogeneous Mutational Signature of Spontaneously Developing Tumors in MLH1-/- Mice.
Yvonne Saara Gladbach,Leonie Wiegele,Mohamed Hamed,Anna-Marie Merkenschlager,Georg Fuellen,Christian Junghanss,Claudia Maletzki +6 more
TL;DR: This present study is the first reporting results of a comparison between spontaneously developing tumors in MMR-D driven tumorigenesis and identifying ARID1A as potential causative mutation hotspot, and a comprehensive characterization of the mutational landscape.
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Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies.
Daniel Strüder,Theresa Momper,Nina Irmscher,Mareike Krause,Jan Liese,Sebastian P. Schraven,Annette Zimpfer,Sarah Zonnur,Ann-Sophie Burmeister,Björn Schneider,Bernhard Frerich,Robert Mlynski,Christina Große-Thie,Christian Junghanss,Claudia Maletzki +14 more
TL;DR: In this article, the authors compared the PDX-take rate, growth, histopathology, and molecular characteristics of endoscopic specimens with surgical specimens and found that PDX was successful in both sample types.
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Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants.
Johannes Mayer,Gesine Reichart,Tursonjan Tokay,Falko Lange,Simone Baltrusch,Christian Junghanss,Olaf Wolkenhauer,Robert Jaster,Manfred Kunz,Markus Tiedge,Saleh M. Ibrahim,Georg Fuellen,Rüdiger Köhling +12 more
TL;DR: Evidence is provided that a single point mutation in complex I of the respiratory chain is associated with impairment of spatial navigation in adolescent (6-month-old) mice and a possible impact of complex I dysfunction on the emergence of neurological deficits is highlighted.
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Combined vaccine-immune-checkpoint inhibition constitutes a promising strategy for treatment of dMMR tumors.
Inken Salewski,Steffen Kuntoff,Andreas Kuemmel,Rico Feldtmann,Stephan B. Felix,Larissa Henze,Christian Junghanss,Claudia Maletzki +7 more
TL;DR: By successful uncoupling of the PD-1/PD-L1 axis, this trial provides further evidence for the safe and successful application of immunotherapies to combat dMMR-driven malignancies that warrants further investigation.