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Christian Le Gouill
Researcher at Université de Montréal
Publications - 54
Citations - 2103
Christian Le Gouill is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 26, co-authored 51 publications receiving 1727 citations. Previous affiliations of Christian Le Gouill include Université de Sherbrooke & University of California, Los Angeles.
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Journal ArticleDOI
Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET.
Yoon Namkung,Christian Le Gouill,Viktoria Lukashova,Hiroyuki Kobayashi,Mireille Hogue,Etienne Khoury,Mideum Song,Michel Bouvier,Stéphane A. Laporte +8 more
TL;DR: New bioluminescence resonance energy transfer (BRET) sensors to quantitatively monitor G protein-coupled receptors (GPCRs) and β-arrestin trafficking are presented and allow quantitative pharmacological studies of GPCR trafficking in real time, in live cells, revealing ligand-dependent biased trafficking of receptor/β-Arrestin complexes.
Journal ArticleDOI
The long and the short cycle. Alternative intracellular routes for trafficking of G-protein-coupled receptors.
TL;DR: The data suggest that the inactivation of the domain, possibly by dephosphorylation, triggers the return of the receptor from the perinuclear compartment to the plasma membrane, which interrupts its transit via the “long cycle.”
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Functional Selectivity of Natural and Synthetic Prostaglandin EP4 Receptor Ligands
Martin Leduc,Billy Breton,Céline Galés,Christian Le Gouill,Michel Bouvier,Sylvain Chemtob,Nikolaus Heveker +6 more
TL;DR: The potencies and efficacies of a panel of EP4 ligands for activation of Gαs, Gαi, and β-arrestin relative to the endogenous ligand PGE2 are determined and suggest considerable functional selectivity among the tested, structurally related agonists.
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Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity
Patricia René,Christian Le Gouill,Irina D. Pogozheva,Gary Lee,Henry I. Mosberg,I. Sadaf Farooqi,Kenneth J. Valenzano,Michel Bouvier +7 more
TL;DR: This pharmacological chaperone may represent a candidate for the development of a targeted therapy suitable for a large subset of patients with MC4R-deficient obesity, and suggest a structure-activity relationship between compounds and mutant receptor conformations that may open a path toward personalized therapy.
Journal ArticleDOI
A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway *
Eugénie Goupil,Danaë Tassy,Carine B. Bourguet,Christiane Quiniou,Veronica Wisehart,Darlaine Pétrin,Christian Le Gouill,Dominic Devost,Hans H. Zingg,Michel Bouvier,Horacio Uri Saragovi,Sylvain Chemtob,Sylvain Chemtob,William D. Lubell,Audrey Claing,Terence E. Hébert,Stéphane A. Laporte +16 more
TL;DR: Findings regarding the allosteric and biased nature of PDC113.824 offer new mechanistic insights into FP receptor signaling relevant to parturition and suggest novel therapeutic opportunities for the development of new tocolytic drugs.