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Audrey Claing
Researcher at Université de Montréal
Publications - 70
Citations - 4580
Audrey Claing is an academic researcher from Université de Montréal. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 31, co-authored 70 publications receiving 4281 citations. Previous affiliations of Audrey Claing include Howard Hughes Medical Institute & Université de Sherbrooke.
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Journal ArticleDOI
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
Randy A. Hall,Richard T. Premont,Chung-Wai Chow,Jeremy T. Blitzer,Julie A. Pitcher,Audrey Claing,Robert H. Stoffel,Robert H. Stoffel,Larry S. Barak,Shirish Shenolikar,Edward J. Weinman,Edward J. Weinman,Edward J. Weinman,Sergio Grinstein,Robert J. Lefkowitz +14 more
TL;DR: It is reported here a direct agonist-promoted association of the β2-adrenergic receptor with the Na+/H+ exchanger regulatory factor (NHERF), a protein that regulates the activity of the Na-H- exchanger type 3 (NHE3).
Journal ArticleDOI
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
TL;DR: The role of GRKs and beta-arrestins are discussed, two families of key regulatory proteins that regulate G protein-coupled receptor endocytosis, and the details regarding the sequence of these interactions and the cross-talk between signaling pathways containing the different protein complexes are revealed are summarized.
Journal ArticleDOI
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
Richard T. Premont,Audrey Claing,Nicolas Vitale,Jennifer L. Freeman,Julie A. Pitcher,Walter A. Patton,Joel Moss,Martha Vaughan,Robert J. Lefkowitz +8 more
TL;DR: An essential role for ARF proteins in regulating beta2-adrenergic receptor endocytosis is suggested through regulation of ARF protein activation by GRK-mediated recruitment of the GIT1 ARF GAP to the plasma membrane.
Journal ArticleDOI
G protein-coupled receptors stimulation and the control of cell migration.
Mathieu Cotton,Audrey Claing +1 more
TL;DR: The role of GPCR mediated signal transduction and their importance in the regulation of actin remodeling leading to cell migration are reviewed.
Journal ArticleDOI
β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis
Audrey Claing,Wei Chen,William E. Miller,Nicolas Vitale,Joel Moss,Richard T. Premont,Robert J. Lefkowitz +6 more
TL;DR: The agonists-driven formation of a complex including β-arrestin, ARNO, and ARF6 provides a molecular mechanism that explains how the agonist-stimulated receptor recruits a small G protein necessary for the endocytic process and controls its activation.