C
Céline Galés
Researcher at University of Toulouse
Publications - 86
Citations - 4343
Céline Galés is an academic researcher from University of Toulouse. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 32, co-authored 73 publications receiving 3776 citations. Previous affiliations of Céline Galés include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes
Céline Galés,Joost J J Van Durm,Stéphane Schaak,Stéphanie M. Pontier,Yann Percherancier,Martin Audet,Hervé Paris,Michel Bouvier +7 more
TL;DR: This work proposes a model wherein agonist binding induces conformational reorganization of a preexisting receptor–G protein complex, leading the Gα-Gβγ interface to open but not dissociate, thus reflecting the initial activation event.
Journal ArticleDOI
Real-time monitoring of receptor and G-protein interactions in living cells
Céline Galés,R. Victor Rebois,Mireille Hogue,Phan Trieu,Andreas Breit,Terence E. Hébert,Terence E. Hébert,Michel Bouvier +7 more
TL;DR: A bioluminescence resonance energy transfer assay that directly monitors in real time the early interactions between human GPCRs and their cognate G-protein subunits in living human cells provides a novel tool to directly probe the dynamics and selectivity of receptor-mediated, G- protein activation-deactivation cycles.
Journal ArticleDOI
Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.
Eneko Urizar,Lucia Montanelli,Tiffany Loy,Marco Bonomi,Stéphane Swillens,Céline Galés,Michel Bouvier,Guillaume Smits,Gilbert Vassart,Sabine Costagliola +9 more
TL;DR: This study is the first report of homodimerization associated with negative cooperativity in rhodopsin‐like GPCRs, and may warrant revisitation of allosterism in the whole GPCR family.
Journal ArticleDOI
The experimental power of FR900359 to study Gq-regulated biological processes
Ramona Schrage,Anna Lena Schmitz,Evelyn Gaffal,Suvi Annala,Stefan Kehraus,Daniela Wenzel,Katrin M. Büllesbach,Tobias Bald,Asuka Inoue,Asuka Inoue,Yuji Shinjo,Ségolène Galandrin,Naveen Shridhar,Michael Hesse,Manuel Grundmann,Nicole Merten,Thomas H. Charpentier,Matthew K. Martz,Adrian J. Butcher,Tanja Slodczyk,Sylvain Armando,Maike Effern,Yoon Namkung,Laura Jenkins,Velten Horn,Anne Stößel,Harald Dargatz,Daniel Tietze,Diana Imhof,Céline Galés,Christel Drewke,Christa E. Müller,Michael Hölzel,Graeme Milligan,Andrew B. Tobin,Jesus Gomeza,Henrik G. Dohlman,John Sondek,T. Kendall Harden,Michel Bouvier,Stéphane A. Laporte,Junken Aoki,Junken Aoki,Bernd K. Fleischmann,Klaus Mohr,Gabriele M. König,Thomas Tüting,Evi Kostenis +47 more
TL;DR: The plant-derived depsipeptide FR900359 is systematically characterize as a selective inhibitor of Gq/11/14 over all other mammalian Gα isoforms and elaborate its molecular mechanism of action.
Journal ArticleDOI
Deciphering biased-agonism complexity reveals a new active AT1 receptor entity
Aude Saulière,Morgane Bellot,Hervé Paris,Colette Denis,Frédéric Finana,Jonas Tind Hansen,Marie-Françoise Altié,Marie-Hélène Seguelas,Atul Pathak,Jakob Lerche Hansen,Jean-Michel Senard,Céline Galés +11 more
TL;DR: New, highly sensitive and direct bioluminescence resonance energy transfer-based G protein activation probes specific for all G protein isoforms are developed and used to evaluate the G protein-coupling activity of angiotensin II, a biased agonist that may stabilize and create a new distinct active pharmacological receptor entity.