C
Christian P. R. Hackenberger
Researcher at Humboldt University of Berlin
Publications - 174
Citations - 5107
Christian P. R. Hackenberger is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Native chemical ligation & Chemistry. The author has an hindex of 34, co-authored 162 publications receiving 4244 citations. Previous affiliations of Christian P. R. Hackenberger include Massachusetts Institute of Technology & Leibniz Institute for Neurobiology.
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Journal ArticleDOI
Chemoselective Ligation and Modification Strategies for Peptides and Proteins
TL;DR: This Review summarizes recent developments in the field of chemoselective ligation and modification strategies and illustrates their application, with examples ranging from the total synthesis of proteins to the semisynthesis of naturally modified proteins.
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Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability
Nicole Nischan,Henry D. Herce,Henry D. Herce,Francesco Di Natale,Nina Bohlke,Nediljko Budisa,M. Cristina Cardoso,Christian P. R. Hackenberger,Christian P. R. Hackenberger +8 more
TL;DR: The findings reveal that the cyclic-CPP-GFP conjugates are internalized into live cells with immediate bioavailability in the cytosol and the nucleus, whereas linear CPP analogues do not confer GFP transduction.
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Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells
Henry D. Herce,Dominik Schumacher,Anselm F. L. Schneider,Anne K. Ludwig,Florian A. Mann,Marion Fillies,Marc-André Kasper,Stefan Reinke,Eberhard Krause,Heinrich Leonhardt,M. Cristina Cardoso,Christian P. R. Hackenberger +11 more
TL;DR: This strategy for the non-endocytic delivery of two recombinant nanobodies into living cells enabled the relocalization of the polymerase clamp PCNA and tumour suppressor p53 to the nucleolus, and thereby allowed the detection of protein-protein interactions that involve these two proteins in living cells.
Journal ArticleDOI
Chemoselektive Ligations‐ und Modifikationsstrategien für Peptide und Proteine
TL;DR: In this article, aufsatz fasst die aktuellen Entwickungen auf dem Gebiet der chemoselektiven Ligations-and Modifikationsstrategien zusammen and illustriert ihre Anwendbarkeit an Beispielen aus der chemischen Totalsynthese von Proteinen bis hin zur Semisynthese naturlicher modifizierter Proteine.
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Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.
Dominik Schumacher,Dominik Schumacher,Jonas Helma,Anselm F. L. Schneider,Heinrich Leonhardt,Christian P. R. Hackenberger +5 more
TL;DR: Nanobodies can be seen as next‐generation tools for the recognition and modulation of antigens that are inaccessible to conventional antibodies and their chemical functionalization opens the way towards promising diagnostic and therapeutic applications.