C
Christian Weyer
Researcher at Amylin Pharmaceuticals
Publications - 103
Citations - 18814
Christian Weyer is an academic researcher from Amylin Pharmaceuticals. The author has contributed to research in topics: Insulin & Pramlintide. The author has an hindex of 59, co-authored 103 publications receiving 18015 citations. Previous affiliations of Christian Weyer include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.
Christian Weyer,Tohru Funahashi,Sachiyo Tanaka,Kikuko Hotta,Yuji Matsuzawa,Richard E. Pratley,P. Antonio Tataranni +6 more
TL;DR: It is confirmed that obesity and type 2 diabetes are associated with low plasma adiponectin concentrations in different ethnic groups and indicate that the degree of hypoadiponectinemia is more closely related to thedegree of insulin resistance and hyperinsulinemia than to the level of adiposity and glucose intolerance.
Journal ArticleDOI
Circulating Ghrelin Levels Are Decreased in Human Obesity
Matthias H. Tschöp,Christian Weyer,P. Antonio Tataranni,Viswanath Devanarayan,Eric Ravussin,Mark L. Heiman +5 more
TL;DR: Plasma ghrelin concentration was decreased in obese Caucasians as compared with lean Caucasians and was lower in Pima Indians, a population with a very high prevalence of obesity, compared with Caucasians.
Journal ArticleDOI
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus.
TL;DR: Defects in insulin secretion and insulin action occur early in the pathogenesis of diabetes, and intervention to prevent diabetes should target both abnormalities.
Journal ArticleDOI
Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance.
TL;DR: Although enlarged mean subcutaneous abdominal adipocyte size is associated with insulin resistance cross-sectionally, prospectively, both abnormalities are independent and additive predictors of Type II diabetes.
Journal ArticleDOI
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion.
Barbora Vozarova,Christian Weyer,Kristin Hanson,P. Antonio Tataranni,Clifton Bogardus,Richard E. Pratley +5 more
TL;DR: Fasting plasma IL- 6 concentrations are positively related to adiposity and negatively related to insulin action in Pima Indians, and the relationship between IL-6 and insulin action seems to be mediated through adiposity.