C
Christina M. Ferrer
Researcher at Drexel University
Publications - 17
Citations - 1171
Christina M. Ferrer is an academic researcher from Drexel University. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 11, co-authored 16 publications receiving 851 citations. Previous affiliations of Christina M. Ferrer include Harvard University & Broad Institute.
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Journal ArticleDOI
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.
Christina M. Ferrer,Thomas P. Lynch,Valerie L. Sodi,John N. Falcone,Luciana P. Schwab,Danielle L. Peacock,David J. Vocadlo,Tiffany N. Seagroves,Mauricio J. Reginato +8 more
TL;DR: It is demonstrated that O-GlcNAcylation regulates cancer cell metabolic reprograming and survival stress signaling via regulation of HIF-1α and its transcriptional target GLUT1.
Journal ArticleDOI
Critical Role of O-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis
Thomas P. Lynch,Christina M. Ferrer,S. RaElle Jackson,Kristina S. Shahriari,Keith Vosseller,Mauricio J. Reginato +5 more
TL;DR: The data suggest that as prostate cancer cells alter glucose and glutamine levels, O-GlcNAc modifications and OGT levels become elevated and are required for regulation of malignant properties, implicating OGT as a novel therapeutic target in the treatment of cancer.
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O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling
TL;DR: This review summarizes the current understanding of changes of O-GlcNAc cycling enzymes in cancer, the role in tumorigenesis, and the current challenges in targeting this pathway therapeutically.
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SIRT6, a Mammalian Deacylase with Multitasking Abilities.
TL;DR: This Review will attempt to provide a framework for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities.
Journal ArticleDOI
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Christina M. Ferrer,Tong Y. Lu,Zachary A. Bacigalupa,Christos D. Katsetos,David A. Sinclair,Mauricio J. Reginato +5 more
TL;DR: O-GlcNAcylation is a central component linking metabolism to invasion and metastasis via an SIRT1/ERK/FOXM1 axis and is dependent on the NAD+-dependent deacetylase Sirt1.