Mauricio J. Reginato

TL;DR: In vitro three-dimensional epithelial cell cultures are utilized to analyze the role of apoptosis in the formation and maintenance of a hollow glandular architecture and show that apoptosis can counteract increased proliferation to maintain luminal space.

TL;DR: Investigating a potential mechanism whereby transcriptional activation by PPARγ may be modulated by growth factor or cytokine-stimulated signal transduction pathways involved in adipogenesis finds phosphorylation of a mitogen-activated protein kinase site in the A/B region ofPPARγ inhibits both ligand-independent and lig and-dependent transactivation functions.

TL;DR: Bim functions as a key sensor of integrin and growth factor signals to the Erk pathway, and loss of such coordinate regulation may contribute to tumour progression.

TL;DR: Findings identify O-GlcNAc as a novel mechanism through which alterations in glucose metabolism regulate cancer growth and invasion and suggest that OGT may represent novel therapeutic targets for breast cancer.

TL;DR: The ability of the A/B domain to regulate ligand binding has important implications for the evaluation and mechanism of action of potentially therapeutic ligands that bind PPAR-γ and that are likely to extend to other members of the nuclear-receptor superfamily.