O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling
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TLDR
This review summarizes the current understanding of changes of O-GlcNAc cycling enzymes in cancer, the role in tumorigenesis, and the current challenges in targeting this pathway therapeutically.About:
This article is published in Journal of Molecular Biology.The article was published on 2016-08-14 and is currently open access. It has received 215 citations till now. The article focuses on the topics: Flux (metabolism) & Metabolic pathway.read more
Citations
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Glutamine Metabolism in Cancer: Understanding the Heterogeneity.
TL;DR: It is found that there is ample evidence of an essential role for glutamine in tumors and that a variety of factors, including tissue type, the underlying cancer genetics, the tumor microenvironment and other variables such as diet and host physiology collectively influence the role of glutamines in cancer.
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Glucose transporters in cancer - from tumor cells to the tumor microenvironment.
TL;DR: Some of the deregulation mechanisms of glucose transporters, their genetic and pharmacological targeting in cancer, and new functions they may have in nontumor cells of the tumor environment or beyond glucose uptake for glycolysis are discussed.
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Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer
TL;DR: Recent progress in understanding the mechanistic relationship between the hexosamine biosynthetic pathway and cancer is discussed.
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MYC and tumor metabolism: chicken and egg
Francesca R Dejure,Martin Eilers +1 more
TL;DR: The main hypothesis is that regulation of MYC levels is an integral part of the adaptation of cells to nutrient deprivation and that maintaining flexibility of expression is integral to MYC's oncogenic function.
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Metabolic Signaling to the Nucleus in Cancer.
TL;DR: The evidence that, in cancer cells, nutrient availability and oncogenic metabolic reprogramming impact the abundance of key metabolites that regulate signaling and epigenetics is reviewed.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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Hypoxia — a key regulatory factor in tumour growth
TL;DR: Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death, and many elements of the hypoxia-response pathway are good candidates for therapeutic targeting.
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