C
Christina Thirlwell
Researcher at University College London
Publications - 59
Citations - 3100
Christina Thirlwell is an academic researcher from University College London. The author has contributed to research in topics: DNA methylation & Neuroendocrine tumors. The author has an hindex of 28, co-authored 56 publications receiving 2675 citations. Previous affiliations of Christina Thirlwell include University of Exeter & London Research Institute.
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Journal ArticleDOI
Somatic mutation of CDKN1B in small intestine neuroendocrine tumors
Joshua M. Francis,Joshua M. Francis,Adam Kiezun,Alex H. Ramos,Alex H. Ramos,Stefano Serra,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Zhi Rong Qian,Michaela S. Banck,Rahul Kanwar,Amit A. Kulkarni,Anna Karpathakis,Anna Karpathakis,Veronica E. Manzo,Tanupriya Contractor,Juliet Philips,Elizabeth Nickerson,Nam Pho,Susanne M. Hooshmand,Lauren K. Brais,Michael S. Lawrence,Trevor J. Pugh,Aaron McKenna,Andrey Sivachenko,Kristian Cibulskis,Scott L. Carter,Akinyemi I. Ojesina,Akinyemi I. Ojesina,Samuel S. Freeman,Robert T. Jones,Douglas Voet,Gordon Saksena,Daniel Auclair,Robert C. Onofrio,Erica Shefler,Carrie Sougnez,Jonna Grimsby,Lisa Green,Niall J. Lennon,Tim Meyer,Tim Meyer,Martyn Caplin,Daniel C. Chung,Andreas S. Beutler,Shuji Ogino,Christina Thirlwell,Christina Thirlwell,Ramesh A. Shivdasani,Sylvia L. Asa,Sylvia L. Asa,Chris R. Harris,Gad Getz,Matthew H. Kulke,Matthew Meyerson,Matthew Meyerson +55 more
TL;DR: Recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27 are identified, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs.
Journal ArticleDOI
Immune Reconstitution Inflammatory Syndrome Associated With Kaposi's Sarcoma
Mark Bower,Mark T. Nelson,A. M. Young,Christina Thirlwell,T. Newsom-Davis,S Mandalia,Tony Dhillon,P Holmes,Brian Gazzard,Justin Stebbing +9 more
TL;DR: In the clinical experience HAART could be successfully continued in those with IRIS-associated KS, and in patients with higher CD4 counts, KS-associated edema, and therapy with both protease inhibitors and non-nucleosides together.
Journal ArticleDOI
HIV-associated anal cancer: has highly active antiretroviral therapy reduced the incidence or improved the outcome?
Mark Bower,Thomas Powles,Tom Newsom-Davis,Christina Thirlwell,Justin Stebbing,Sundihya Mandalia,Mark T. Nelson,Brian Gazzard +7 more
TL;DR: Unlike other HIV-associated cancers, there has been no significant change in the incidence, clinical features, or overall survival since the introduction of HAART.
Journal ArticleDOI
Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer.
Andrew E. Teschendorff,Andrew E. Teschendorff,Zhen Yang,Andrew Wong,Christodoulos P. Pipinikas,Yinming Jiao,Allison Jones,Shahzia Anjum,Rebecca Hardy,Helga B. Salvesen,Christina Thirlwell,Sam M. Janes,Diana Kuh,Martin Widschwendter +13 more
TL;DR: Data point toward buccal cells as being a more appropriate source of tissue than blood to conduct EWASs for smoking-related epithelial cancers.
Journal ArticleDOI
Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor
Anna Karpathakis,Anna Karpathakis,Harpreet Dibra,Christodoulos P. Pipinikas,Andrew Feber,Tiffany Morris,Joshua M. Francis,Joshua M. Francis,Dahmane Oukrif,Dalvinder Mandair,Dalvinder Mandair,Marinos Pericleous,Mullan Mohmaduvesh,Stefano Serra,Olagunju Ogunbiyi,Marco Novelli,Tu Vinh Luong,Sylvia L. Asa,Matthew H. Kulke,Christos Toumpanakis,Tim Meyer,Tim Meyer,Martyn Caplin,Matthew Meyerson,Matthew Meyerson,Stephan Beck,Christina Thirlwell,Christina Thirlwell +27 more
TL;DR: This first comprehensive integrated molecular analysis of SINETs has demonstrated that these tumors are highly epigenetically dysregulated, and has identified novel molecular subtypes with significant impact on progression-free survival.