Lisa Green

TL;DR: It is concluded that the early control of HIV-1 replication by immunodominant CD8+ T cell responses may be substantially influenced by rapid, low frequency viral adaptations not detected by conventional sequencing approaches, which warrants further investigation.

TL;DR: Recurrent somatic mutations and deletions in CDKN1B, the cyclin-dependent kinase inhibitor gene, which encodes p27 are identified, nominating p27 as a tumor suppressor and implicating cell cycle dysregulation in the etiology of SI-NETs.

TL;DR: Initial characterization of clinical acquired resistance mechanisms to combined RAF/EGFR or RAF/MEK combinations identified several MAPK pathway alterations driving resistance by reactivating MAPK signaling, highlighting the critical dependence of BRAF-mutant colorectal cancers onMAPK signaling and offering potential strategies to overcome resistance.

TL;DR: An in-depth characterization of the mechanism of sequencer-induced sample contamination due to the phenomenon of index swapping that impacts Illumina sequencers employing patterned flow cells with Exclusion Amplification chemistry is presented and methods for eliminating sample data cross contamination are provided.

TL;DR: An automated, high throughput library construction process for 454 technology, where one technician can create 96 sequence-ready 454 libraries in 2 days, a dramatic improvement over the standard method.