O
Olca Basturk
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 159
Citations - 11343
Olca Basturk is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Pancreas & Carcinoma. The author has an hindex of 46, co-authored 157 publications receiving 8677 citations. Previous affiliations of Olca Basturk include New York University & Institute of Molecular Pathology and Immunology of the University of Porto.
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Journal ArticleDOI
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Sylvia F. Boj,Chang-Il Hwang,Chang-Il Hwang,Lindsey A. Baker,Lindsey A. Baker,Iok In Christine Chio,Iok In Christine Chio,Dannielle D. Engle,Dannielle D. Engle,Vincenzo Corbo,Vincenzo Corbo,Myrthe Jager,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Hervé Tiriac,Hervé Tiriac,Mona S. Spector,Mona S. Spector,Ana Gracanin,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Kenneth H. Yu,Ruben van Boxtel,Meritxell Huch,Keith Rivera,John P. Wilson,Michael E. Feigin,Michael E. Feigin,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Christine M. Ardito-Abraham,Christine M. Ardito-Abraham,Michael Ludwig,Michael Ludwig,Ela Elyada,Ela Elyada,Brinda Alagesan,Brinda Alagesan,Brinda Alagesan,Giulia Biffi,Giulia Biffi,Georgi N. Yordanov,Georgi N. Yordanov,Bethany Delcuze,Bethany Delcuze,Brianna Creighton,Brianna Creighton,Kevin Wright,Kevin Wright,Young-Kyu Park,Young-Kyu Park,Folkert H.M. Morsink,I. Quintus Molenaar,Inne H.M. Borel Rinkes,Edwin Cuppen,Yuan Hao,Ying Jin,Isaac J. Nijman,Christine A. Iacobuzio-Donahue,Steven D. Leach,Darryl J. Pappin,Molly Hammell,David S. Klimstra,Olca Basturk,Ralph H. Hruban,G. J. A. Offerhaus,Robert G.J. Vries,Hans Clevers,David A. Tuveson,David A. Tuveson,David A. Tuveson +73 more
TL;DR: Comprehensive transcriptional and proteomic analyses of murine pancreatic organoids revealed genes and pathways altered during disease progression that demonstrate that organoids are a facile model system to discover characteristics of this deadly malignancy.
Journal ArticleDOI
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.
Vinod P. Balachandran,Marta Łuksza,Julia N. Zhao,Vladimir Makarov,John Alec Moral,Romain Remark,Brian Herbst,Gokce Askan,Umesh Bhanot,Yasin Senbabaoglu,Daniel K. Wells,Charles Ian Ormsby Cary,Olivera Grbovic-Huezo,Marc A. Attiyeh,Benjamin D. Medina,Jennifer Q. Zhang,Jennifer K. Loo,Joseph Saglimbeni,Mohsen Abu-Akeel,Roberta Zappasodi,Nadeem Riaz,Martin Smoragiewicz,Z. Larkin Kelley,Z. Larkin Kelley,Olca Basturk,Amber L. Johns,R. Scott Mead,Anthony J. Gill,David K. Chang,David K. Chang,Skye McKay,Lorraine A. Chantrill,Venessa T. Chin,Angela Chou,Jeremy L. Humphris,Marina Pajic,Angela Steinmann,Mehreen Arshi,Mehreen Arshi,Ali Drury,Danielle Froio,Danielle Froio,Ashleigh Morgan,Paul Timpson,David Hermann,Claire Vennin,Sean C. Warren,Mark Pinese,Jianmin Wu,Andreia V. Pinho,Katherine Tucker,Lesley Andrews,Jaswinder S. Samra,Jennifer Arena,Jennifer Arena,Nick Pavlakis,Hilda High,Anubhav Mittal,Andrew V. Biankin,Peter Bailey,Sancha Martin,Elizabeth A. Musgrove,Marc D. Jones,Marc D. Jones,Craig Nourse,Nigel B. Jamieson,Alina Stoita,David Williams,Allan D. Spigelman,Nicola Waddell,John V. Pearson,Ann-Marie Patch,Katia Nones,Felicity Newell,Pamela Mukhopadhyay,Venkateswar Addala,Stephen H. Kazakoff,Oliver Holmes,Conrad Leonard,Scott Wood,Christina Xu,Sean M. Grimmond,Oliver Hofmann,Peter Wilson,Angelika N. Christ,Timothy J. C. Bruxner,Ray Asghari,Neil D. Merrett,Darren Pavey,Amitabha Das,Annabel Goodwin,Peter H. Cosman,Kasim Ismail,Chelsie O'Connor,Caroline Cooper,Peter Grimison,James G. Kench,Charbel Sandroussi,Vincent Lam,Duncan J. Mcleod,Adnan Nagrial,Judy Kirk,Virginia James,Michael Texler,Cindy Forest,Krishna Epari,Mo Ballal,David R. Fletcher,Sanjay Mukhedkar,Nikolajs Zeps,Maria Beilin,Kynan Feeney,Nan Q. Nguyen,Andrew Ruszkiewicz,Chris Worthley,John W. Chen,Mark Brooke-Smith,Virginia Papangelis,Andrew D. Clouston,P. Martin,Andrew Barbour,Thomas J. O'Rourke,Jonathan Fawcett,Kellee Slater,Michael Hatzifotis,Peter Hodgkinson,Mehrdad Nikfarjam,James R. Eshleman,Ralph H. Hruban,Christopher L. Wolfgang,Mary Hodgin,Aldo Scarpa,Rita T. Lawlor,Stefania Beghelli,Vincenzo Corbo,Maria Scardoni,Claudio Bassi,Mithat Gonen,Arnold J. Levine,Peter J. Allen,Douglas T. Fearon,Douglas T. Fearon,Miriam Merad,Sacha Gnjatic,Christine A. Iacobuzio-Donahue,Jedd D. Wolchok,Ronald P. DeMatteo,Timothy A. Chan,Benjamin Greenbaum,Taha Merghoub,Taha Merghoub,Steven D. Leach +151 more
TL;DR: In this paper, the authors used genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer.
Journal ArticleDOI
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Olca Basturk,Seung-Mo Hong,Laura D. Wood,N. Volkan Adsay,Jorge Albores-Saavedra,Andrew V. Biankin,Lodewijk A.A. Brosens,Noriyoshi Fukushima,Michael Goggins,Ralph H. Hruban,Yo Kato,David S. Klimstra,Günter Klöppel,Alyssa M. Krasinskas,Daniel S. Longnecker,Hanno Matthaei,G. Johan A. Offerhaus,Michio Shimizu,Kyoichi Takaori,Benoit Terris,Shinichi Yachida,Irene Esposito,Toru Furukawa +22 more
TL;DR: International experts met to discuss recent advances and to revise the 2004 recommendations for assessing and reporting precursor lesions to invasive carcinomas of the pancreas, including pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMN), mucinous cystic neoplasm, and other lesions.
Journal ArticleDOI
Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas.
N. Volkan Adsay,Kambiz Merati,Olca Basturk,Christine A. Iacobuzio-Donahue,Edi Levi,Jeanette D. Cheng,Fazlul H. Sarkar,Ralph H. Hruban,David S. Klimstra +8 more
TL;DR: IPNs include pathologically and biologically distinct epithelial patterns that support the existence of an intestinal pathway of carcinogenesis, and the presence of intestinal differentiation may potentially be used in prognostication and stratification of patients into appropriate treatment categories.
Journal ArticleDOI
The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms.
Olca Basturk,Zhaohai Yang,Laura H. Tang,Ralph H. Hruban,N. Volkan Adsay,Chad M. McCall,Alyssa M. Krasinskas,Kee-Taek Jang,Wendy L. Frankel,Serdar Balci,Carlie S. Sigel,David S. Klimstra +11 more
TL;DR: It is demonstrated that well differentiated PanNETs that are G3 by Ki67 are significantly less aggressive than bona fide poorly differentiated NECs, suggesting that the current World Health Organization G3 category is heterogenous, contains 2 distinct neoplasms, and can be further separated into well differentiatedPanNET with an elevated proliferation rate and well differentiated NEC.