C
Christine B. Kern
Researcher at Medical University of South Carolina
Publications - 35
Citations - 1984
Christine B. Kern is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Versican & Heart development. The author has an hindex of 20, co-authored 34 publications receiving 1774 citations. Previous affiliations of Christine B. Kern include Sewanee: The University of the South.
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Journal ArticleDOI
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
Russell A. Norris,Brook Damon,Vladimir Mironov,Vladimir Kasyanov,Anand Ramamurthi,Anand Ramamurthi,Ricardo A. Moreno-Rodriguez,Thomas C. Trusk,Jay D. Potts,Richard L. Goodwin,Jeffrey Davis,Stanley Hoffman,Xuejun Wen,Yukiko Sugi,Christine B. Kern,Corey H. Mjaatvedt,Debi Turner,Toru Oka,Simon J. Conway,Jeffery D. Molkentin,Gabor Forgacs,Roger R. Markwald +21 more
TL;DR: Functional biomechanical properties of periostin null skin specimens and atrioventricular valve explant experiments provided direct evidence of the role that periastin plays in regulating the viscoelastic properties of connective tissues.
Journal ArticleDOI
Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.
Christine B. Kern,Andy Wessels,Jessica D. McGarity,Laura J. Dixon,Ebony Alston,W. Scott Argraves,Danielle Geeting,Courtney M. Nelson,Donald R. Menick,Suneel S. Apte +9 more
TL;DR: It is demonstrated that ADAMTS9, a highly conserved versican-degrading protease, is required for correct cardiovascular development and adult homeostasis and that mouse models of ADAMts9 deficiency may be useful to study myxomatous valve degeneration.
Journal ArticleDOI
Origin and fate of cardiac mesenchyme.
TL;DR: The current understanding of the role of cardiac mesenchyme in cardiac morphogenesis is reviewed and several new paradigms based on recent studies in the mouse are discussed.
Journal ArticleDOI
Proteolytic cleavage of versican during cardiac cushion morphogenesis.
Christine B. Kern,Waleed O. Twal,Corey H. Mjaatvedt,Sarah E. Fairey,Bryan P. Toole,M. Luisa Iruela-Arispe,W. Scott Argraves +6 more
TL;DR: The findings reveal that versican proteolysis leading to the production of the 70‐kDa fragment is integral to the formation and differentiation of endocardial cushion mesenchymal cells in the cushion core.
Journal ArticleDOI
Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.
Loren E. Dupuis,Daniel R. McCulloch,Jessica D. McGarity,Alexandria Bahan,Andy Wessels,Deidra Weber,A. Megan Diminich,Courtney M. Nelson,Suneel S. Apte,Christine B. Kern +9 more
TL;DR: Data suggest that ECM remodeling via ADAMTS5 is required for endocardial to mesenchymal signaling in late fetal valve development, and hypothesize that a lack of versican cleavage during fetal valves development may be a potential etiology of adult myxomatous valve disease.