T
Toru Oka
Researcher at Chiba University
Publications - 9
Citations - 2105
Toru Oka is an academic researcher from Chiba University. The author has contributed to research in topics: GATA4 & Periostin. The author has an hindex of 8, co-authored 9 publications receiving 1908 citations. Previous affiliations of Toru Oka include Boston Children's Hospital & University of Cincinnati.
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Journal ArticleDOI
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
Russell A. Norris,Brook Damon,Vladimir Mironov,Vladimir Kasyanov,Anand Ramamurthi,Anand Ramamurthi,Ricardo A. Moreno-Rodriguez,Thomas C. Trusk,Jay D. Potts,Richard L. Goodwin,Jeffrey Davis,Stanley Hoffman,Xuejun Wen,Yukiko Sugi,Christine B. Kern,Corey H. Mjaatvedt,Debi Turner,Toru Oka,Simon J. Conway,Jeffery D. Molkentin,Gabor Forgacs,Roger R. Markwald +21 more
TL;DR: Functional biomechanical properties of periostin null skin specimens and atrioventricular valve explant experiments provided direct evidence of the role that periastin plays in regulating the viscoelastic properties of connective tissues.
Journal ArticleDOI
Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling
Toru Oka,Jian Xu,Jian Xu,Robert A. Kaiser,Robert A. Kaiser,Jaime Melendez,Jaime Melendez,Michael Hambleton,Michael Hambleton,Michelle A. Sargent,Michelle A. Sargent,A. Lorts,A. Lorts,Eric W. Brunskill,Eric W. Brunskill,Gerald W. Dorn,Gerald W. Dorn,Simon J. Conway,Bruce J. Aronow,Bruce J. Aronow,Jeffrey Robbins,Jeffrey Robbins,Jeffery D. Molkentin,Jeffery D. Molkentin +23 more
TL;DR: It is shown that Pn is critically involved in regulating the cardiac hypertrophic response, interstitial fibrosis, and ventricular remodeling following long-term pressure overload stimulation and myocardial infarction.
Journal ArticleDOI
Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability
Toru Oka,Marjorie Maillet,Alistair J. Watt,Robert J. Schwartz,Bruce J. Aronow,Stephen A. Duncan,Jeffery D. Molkentin +6 more
TL;DR: Examination of gene expression profiles in the heart revealed a number of profound alterations in known GATA4-regulated structural genes as well as genes with apoptotic implications, indicating that Gata4 is a necessary regulator of cardiac gene expression, hypertrophy, stress-compensation, and myocyte viability.
Journal ArticleDOI
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart
Joerg Heineke,Mannix Auger-Messier,Jian Xu,Toru Oka,Michelle A. Sargent,Allen J. York,Raisa Klevitsky,Sachin Vaikunth,Stephen A. Duncan,Bruce J. Aronow,Jeffrey Robbins,Timothy M. Cromblehol,Jeffery D. Molkentin +12 more
TL;DR: To the authors' knowledge, these results demonstrate a previously unrecognized function for GATA4 as a regulator of cardiac angiogenesis through a nonhypoxic, load, and/or disease-responsive mechanism.
Journal ArticleDOI
Re-employment of developmental transcription factors in adult heart disease.
TL;DR: This review will discuss the transcription factors that regulate the hypertrophic growth response of the adult heart, with a special emphasis on those regulators that participate in cardiac development.